Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People diagnosed with advanced non-small cell lung cancer (either at an advanced stage from the start, or cancer that has come back), confirmed by laboratory testing of tissue or cell samples.
• People who have cancer that has spread to the brain and are being considered for whole-brain radiation therapy.
• People whose cancer has a specific genetic change in the EGFR gene known as a "sensitivity mutation."
• People whose cancer can be measured using a specific set of standards used to track brain metastases (confirm with trial site).
• People aged 18 years or older.
• People who are reasonably active and able to carry out daily activities, as rated on a standard functional scale (ECOG score of 0–2).
• People with a life expectancy of at least 12 weeks.
• People who are not currently taking a type of blood pressure medication called calcium channel blockers.
• People who have had an electrocardiogram (a heart tracing test) performed (confirm with trial site for timing requirements).
• People whose blood counts meet minimum levels: enough white blood cells (neutrophils) and platelets, as measured by a blood test.
• People whose liver and kidney function blood test results fall within acceptable ranges as defined by the trial.
• People who are able and willing to follow the study procedures and attend follow-up appointments.
• People who have provided written, signed consent to participate.
• People who have stored tumour tissue (from a biopsy taken before any systemic treatment) available for testing.

Who may not be able to join:

• People with an unstable or serious ongoing illness, such as an active infection, very high blood pressure, unstable chest pain, heart failure, heart disease, or significant liver or kidney disease.
• People with a known allergy to a substance called glyceryl tinistate (confirm with trial site).
• People who have had another type of cancer in the past 5 years, except for certain early-stage or easily treated cancers such as cervical carcinoma in situ or basal cell skin cancer that have been appropriately treated.
• People who are pregnant or breastfeeding.
• People whose cancer has spread to the membranes surrounding the brain and spinal cord, confirmed by laboratory testing of fluid samples.

A person may be removed from the trial if:

• The trial's protocol rules are not followed.
• Contact with the participant is lost during follow-up.
• The participant decides they no longer wish to continue.
• The participant experiences side effects that are considered unacceptable.

Important: Always verify eligibility with the trial site directly before applying.