Phase 2 Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People whose general physical functioning is rated as reasonably good by their doctor (on a standard scale used in cancer care, scored 0–2)
• People who have been diagnosed with small cell lung cancer, confirmed through a tissue or cell sample
• People who have had a full set of baseline scans completed before starting any first-line treatment, including brain scans, full-body imaging, and other relevant imaging
• People newly diagnosed with extensive-stage small cell lung cancer that has spread to the brain, who are planned to receive at least 4 cycles of standard chemotherapy (platinum-based, two-drug combination) together with immunotherapy (a PD-1 or PD-L1 antibody treatment) as their first treatment, and whose organ function meets the trial requirements as assessed by the doctor
• People whose brain metastases meet specific criteria for a targeted radiation treatment called stereotactic radiosurgery (SRS) — this means no more than 10 brain tumours, each tumour smaller than 3 cm across and under 10 ml in volume, total tumour volume under 15 ml, and no spread to the lining of the brain
• People with no history of other cancers
• Men and women of childbearing age who agree to use contraception during the trial (such as surgical sterilisation, oral contraceptives, an intrauterine device, or condoms)
• People with a life expectancy of at least 3 months
• People who are able to understand and willingly sign a consent form

Who may not be able to join:

• People whose pathology results show any non-small cell lung cancer component alongside their small cell lung cancer
• People who have already received any cancer treatment before being diagnosed with extensive-stage small cell lung cancer
• People whose scans show cancer has spread to the lining of the brain, or who have symptoms suggesting this
• People who are unable to have a contrast-enhanced MRI scan
• People whose brain metastasis symptoms are severe enough to require emergency surgery to relieve pressure in the brain
• People who are unable to stay still as required for radiation treatment, or who cannot tolerate radiation therapy for any reason
• People with significant active lung disease, such as interstitial lung disease or pneumonia (infectious or non-infectious)
• People who require long-term use of corticosteroids or other immune-suppressing medications
• People who have had an allergic reaction to PD-1 or PD-L1 immunotherapy, or who cannot receive immune maintenance therapy for any other reason
• Women who are pregnant or breastfeeding
• People with serious active autoimmune diseases, such as inflammatory bowel disease (Crohn's disease or ulcerative colitis), rheumatoid arthritis, scleroderma, lupus, or autoimmune blood vessel conditions
• People with other medical findings or uncontrolled conditions that the investigator believes could interfere with trial results or increase the risk of treatment complications
• People with mental illness, substance use issues, or social circumstances that a doctor determines may affect their ability to follow the trial requirements

Important: Always verify eligibility with the trial site directly before applying.