Phase 1 Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 years or older, of any gender.
• Tumor tissue collected during the screening process is available for testing.
• People who have been diagnosed with a specific type of returning or growing brain tumor called IDH-mutant 1p/19q co-deleted Oligodendroglioma (Grade 2 or Grade 3), and whose tumor has come back more than 12 weeks after finishing radiation treatment.
• People who have a general health and ability-to-function score at or above a certain level (a measure doctors use called Karnofsky Performance Status of 60 or higher).
• People who are considered suitable candidates for a surgical procedure or biopsy.
• People whose blood and organ function results fall within acceptable ranges, including blood cell counts, kidney function, and liver function (the trial site can confirm the specific values required).
• Women who could potentially become pregnant must have a negative pregnancy blood test at the time of enrolment.
• People who are able to become pregnant, and their partners, must be willing to use acceptable methods of contraception during the trial.

Who may not be able to join:

• People whose brain tumor continued to grow or spread while they were being treated with a specific type of drug that targets IDH-1 or IDH-2 mutations.
• People who have had another type of cancer in the past, unless they have been cancer-free for 3 or more years (skin cancers that are not melanoma may be an exception).
• People whose brain tumor has spread to certain areas of the brain or to the lining around the brain and spinal cord.
• People whose brain tumor appears in more than one separate location.
• People who are taking steroid medications at a dose equivalent to 4mg or more of dexamethasone per day.
• People who test positive for HIV, Hepatitis B, or Hepatitis C.
• People who have a known active infection or a condition that weakens the immune system.
• People who have an autoimmune disease that requires treatment with medications that suppress the immune system.
• People who are pregnant or breastfeeding, due to possible risks to the developing baby or infant.
• People who have received another experimental drug or treatment within 30 days before the planned start of this trial.
• People with serious active health conditions, including but not limited to: unstable heart conditions or heart failure requiring hospitalisation; a heart attack within the last 6 months; a serious bacterial or fungal infection currently requiring intravenous antibiotics; severe lung disease requiring hospitalisation; significant liver failure causing jaundice or blood clotting problems; AIDS as defined by current medical guidelines; or major physical or mental health conditions that, in the doctor's judgement, would prevent safe participation in the trial.

Important: Always verify eligibility with the trial site directly before applying.