Phase 3 Head and Neck Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are generally well enough to carry out daily activities with little to no limitation (measured by a standard medical scale called ECOG, scoring 0 or 1)
• People who have been diagnosed with squamous cell carcinoma (a type of cancer) in the mouth, including the tongue, gums, cheek, floor of the mouth, hard palate, or the area near the back molars
• People whose cancer is at stage III or IVA, based on specific tumour and lymph node measurements (AJCC 2018 staging system)
• People who have at least one tumour that can be measured using standard imaging criteria (RECIST v1.1)
• People whose blood cell counts fall within acceptable ranges — white blood cells, haemoglobin, and platelets must all be above certain levels
• People whose liver function tests are within an acceptable range (ALT/AST and bilirubin levels below set thresholds)
• People whose kidney function is within an acceptable range (based on a blood test called serum creatinine)
• People whose blood clotting function is within an acceptable range (based on tests called INR, PT, and APTT)
• People who have read and signed the trial's informed consent form

Who may not be able to join:

• People who still have unresolved side effects (grade 2 or higher) from a previous cancer treatment
• People with a known serious allergic reaction (grade 3–4) to any ingredient in the trial treatment
• People with a known history of another cancer, unless it was fully treated and has not returned for at least 5 years
• People who have previously had radiation therapy to the head or neck
• People with a currently active and serious infection (above grade 2 on a standard medical scale)
• People with significant heart problems — such as a recent heart attack, superior vena cava syndrome, or moderate-to-severe heart disease — diagnosed in the 3 months before joining the trial
• People currently receiving any treatment that works through the immune system
• People with a history of active bleeding, a blood clotting disorder, or who are taking a blood-thinning medication called coumarin (warfarin)
• People who are pregnant or breastfeeding
• People with active hepatitis B or hepatitis C, or other serious liver diseases such as autoimmune liver disease, primary biliary cirrhosis, sclerosing cholangitis, alcoholic liver disease, or non-alcoholic steatohepatitis (NASH)
• People with a severe or uncontrolled infection, HIV infection, or a diagnosis of AIDS; or people with an uncontrolled autoimmune disease; or people who have had an organ, tissue, stem cell, bone marrow, or solid organ transplant
• People who have participated in another clinical trial within 30 days before joining this trial
• People whom the trial investigators consider unsuitable for participation for any other reason (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.