Multiple Sclerosis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

For people with Relapsing-Remitting Multiple Sclerosis (RRMS):

• You are between 18 and 55 years old
• You have been diagnosed with RRMS using standard diagnostic guidelines (2017 McDonald criteria)
• Your MRI scan shows at least 9 MS-related spots in the brain
• You have not received a steroid treatment called methylprednisolone in the last month before the study scans
• You are not currently taking any MS medication
• Your doctor has recommended you start a strong MS treatment (such as Natalizumab, an anti-CD20 antibody, Alemtuzumab, a sphingosine-1 phosphate modulator, or cladribine), either because your MS is very active or because you had two or more relapses in the past year
• You are covered by a French social security or health insurance scheme (certain types of medical aid are excluded — confirm with trial site)

For healthy volunteers:

• You are between 18 and 55 years old
• You do not have any ongoing or progressive health conditions
• You are able to understand the goals and procedures of the study
• You are covered by a French social security or health insurance scheme (certain types of medical aid are excluded — confirm with trial site)

Who may not be able to join:

For all participants:

• You have any reason that prevents you from having an MRI scan, such as claustrophobia, a pacemaker, or a metal fragment in your eye
• You have had any medical test involving radioactivity in the last 12 months
• A specific genetic test taken at the screening visit shows you have a "low affinity binding" profile related to a particular protein (confirm with trial site)
• You are pregnant, breastfeeding, or are a woman who could become pregnant and is not using effective contraception
• You currently have serious or uncontrolled problems with your kidneys, liver, blood, digestive system, lungs, heart, or any other long-term neurological condition
• You would not want to be told if an unexpected and medically significant problem were found on your MRI
• You are under any form of legal guardianship or protection
• You are currently taking part in another clinical trial, or you are still within a waiting period after a previous trial

Additional exclusions for RRMS patients only:

• You have a known allergy to gadoteric acid, meglumine, or any medication containing gadolinium (these are contrast dyes used in MRI scans)
• You have severely reduced kidney function (based on specific blood test measurements — confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.