Phase 2 Uveitis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older (but under 65)
• You have been diagnosed with one of the following rare inflammatory conditions, with active disease:
• Behçet's disease that does not currently involve life-, organ-, or sight-threatening symptoms, but is considered active based on a standard scoring system or your doctor's assessment (e.g., you need new or additional medication)
• Dermatomyositis or anti-synthetase syndrome (types of inflammatory muscle disease), confirmed by recognised diagnostic guidelines, with signs of active disease shown by specific blood test results, a muscle scan done within the last 3 months, or your doctor's clinical judgement
• IgG4-related disease, diagnosed using 2019 international guidelines, with active disease shown by a standard scoring tool or your doctor's assessment
• Your condition has not responded well to at least 12 weeks of steroid treatment, plus at least one other immune-suppressing medication (such as methotrexate, azathioprine, mycophenolate mofetil, or rituximab), or you are unable to tolerate standard treatments
• You have no signs of active or latent tuberculosis (TB), confirmed by two negative TB tests done within the past 3 months, a clear chest X-ray, and no history of untreated TB

Who may not be able to join:

• You are under 18 or 65 years of age or older
• Your life expectancy is less than 6 months
• You have a specific type of myositis such as juvenile dermatomyositis, myositis linked to another autoimmune disease, immune-mediated necrotising myopathy, inclusion-body myositis, or cancer-related myositis
• Your muscle weakness is thought to be due to permanent muscle damage rather than active inflammation
• You have a significantly increased risk of major heart or blood vessel problems
• You are a current smoker or have a long history of smoking
• You are pregnant or breastfeeding
• You have previously used a type of medication called a JAK inhibitor
• You have taken an experimental drug within the past month (or longer, depending on the drug)
• You have HIV infection
• You have an active infection, or hepatitis B or C
• You have a history of shingles or repeated herpes simplex infections
• You have been diagnosed with cancer in the last 5 years (with some exceptions for certain minor skin cancers)
• You are considered at increased risk of developing cancer
• Your kidneys are functioning at a very low level (confirm with trial site)
• You have severe liver failure (confirm with trial site)
• Your blood counts (white cells, neutrophils, or haemoglobin) are below certain levels (confirm with trial site)
• You are unable or unlikely to follow the study procedures and attend follow-up appointments
• You have a known recent history of alcohol or drug misuse
• You have difficulty with blood draws or poor vein access for the blood tests required during the study
• You have previously not taken immunosuppressant medications as prescribed
• You are allergic to the study drug or any of its ingredients
• You have a rare inherited condition affecting how your body processes certain sugars, such as galactose intolerance, lactase deficiency, or glucose-galactose malabsorption

Important: Always verify eligibility with the trial site directly before applying.