Phase 2 Endometrial Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with stage IB1 cervical cancer based on a physical examination and MRI scan
• People whose cancer type has been confirmed by a tissue sample as squamous cell carcinoma of the cervix
• People whose cervical transformation zone (the area where cancer commonly develops) is classified as type 1 or 2 (confirm with trial site)
• People whose cancer tissue tests positive for a protein called PD-L1, with a combined score of 1 or higher
• People aged 18 to 45 years old
• People who are generally in good physical health and able to carry out daily activities with little or no limitation (confirm with trial site)
• People whose blood test results meet specific requirements for white blood cells, platelets, liver function, and kidney function
• People who have a strong wish to have children in the future
• People who are willing to sign a consent form and follow the study requirements

Who may not be able to join:

• People with a history of infertility, including cases related to fallopian tube problems or their partner's fertility
• People who have an active autoimmune disease, or a history of one that required ongoing treatment (such as certain conditions affecting the liver, lungs, eyes, bowel, thyroid, or blood vessels)
• People who have previously been treated with certain immune-based cancer therapies (such as anti-PD-1 or anti-PD-L1 drugs), or who have a known allergy to the study medication or similar treatments
• People with a known HIV infection, or active hepatitis B or C
• People who have taken immune-suppressing medications or high-dose steroids within the 2 weeks before the study treatment begins
• People with a history of another cancer, or who have previously had chemotherapy or radiation therapy to the pelvis
• People who are currently taking part in another clinical trial
• People who are pregnant or breastfeeding; the trial also requires effective contraception to be used during treatment and for a set period afterwards
• People with serious or uncontrolled heart conditions, high blood pressure, recent stroke, bleeding disorders, serious infections, or significant liver or kidney problems
• People who have received a live or weakened vaccine within 4 weeks before the first dose (standard flu vaccines are permitted)
• People who have previously had a bone marrow or organ transplant
• People with drug or alcohol dependency
• People who, in the study doctor's opinion, are unlikely to be able to follow the study requirements

Important: Always verify eligibility with the trial site directly before applying.