Phase 2 Endometrial Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with untreated stage IB2 cervical cancer (confirmed by two senior doctors using examination and imaging)
• You have at least one tumour that can be measured on a scan (mainly MRI)
• Your cervical cancer has been confirmed by a tissue sample (biopsy) and is one of these types: squamous cell carcinoma (any grade), usual type adenocarcinoma (certain grades), or adenosquamous carcinoma (certain grades)
• Your tumour tests positive for a protein called PD-L1, with a score of 1 or higher
• You are between 18 and 70 years old
• You are generally well enough to carry out light activity or desk work (your performance score shows you are mostly active)
• Your blood counts, liver, and kidney results are within acceptable ranges as shown by recent lab tests
• You are willing and able to attend follow-up appointments and follow the trial schedule
• You are willing to sign a consent form agreeing to the trial's requirements

Who may not be able to join:

• You have, or have had, an autoimmune disease (where your immune system attacks your own body), unless it is a mild condition such as vitiligo, hair loss, certain skin conditions not needing ongoing treatment, well-controlled thyroid conditions, stable type 1 diabetes, or childhood asthma that has fully resolved
• You have previously been treated with immune checkpoint inhibitor drugs (a type of cancer immunotherapy, such as anti-PD-1 or anti-PD-L1 medicines)
• You have a known allergy to any ingredient in the trial medication
• You have taken strong immune-suppressing medicines or high-dose steroid tablets within the past 2 weeks (certain steroid creams, eye drops, nasal sprays, or inhalers are allowed)
• You have taken certain herbal or immune-boosting treatments within the past 2 weeks
• You currently have a serious infection that requires treatment
• You had a serious infection (such as sepsis or severe pneumonia requiring hospitalisation) within the past 4 weeks
• You have untreated or poorly controlled hepatitis B, or active hepatitis C (stable, treated cases may be eligible — confirm with trial site)
• You have active tuberculosis (TB)
• You have a weakened immune system or are HIV positive
• You have active or past inflammatory bowel disease (such as Crohn's disease or ulcerative colitis), or severe problems swallowing or absorbing medicines
• You have a known lung condition causing scarring or inflammation (interstitial lung disease) that could interfere with treatment
• You have received a live or weakened (attenuated) vaccine within the past 4 weeks (standard inactivated flu vaccines are allowed)
• You have previously had a bone marrow transplant or a solid organ transplant
• You have been diagnosed with another cancer within the past 5 years
• You have had major surgery or serious injury within the past 28 days
• You have a history of a hole in your gut (gastrointestinal perforation), a gut fistula, or a fistula in the female genital area
• You have serious uncontrolled heart or blood vessel problems, including recent heart attack, stroke, blood clots, or severe heart failure within the past 6 months
• You have had significant bleeding (such as from your stomach or gut) within the past month, or currently have active coughing of blood, bowel blockage, or uncontrolled fluid build-up in the body
• You have abnormal liver or kidney development, or a related surgical history (confirm with trial site)
• You are pregnant, breastfeeding, or are of childbearing age and unwilling to use contraception during the treatment period
• You are currently taking part in another clinical trial that involves a treatment or intervention
• Your doctor feels that joining the trial would not be safe or suitable for you for any other reason

Important: Always verify eligibility with the trial site directly before applying.