Phase 2 Oesophageal Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are a male or female aged 18 or older
• You have been diagnosed with a specific type of cancer (adenocarcinoma or squamous cell carcinoma) of the esophagus (food pipe) or the area where the esophagus meets the stomach, confirmed by a biopsy
• Your cancer has either spread to a limited number of places in the body (1–5 spots outside the main treatment area, seen on a special scan), or it is locally advanced and cannot be treated with surgery or high-dose radiation therapy
• You have difficulty swallowing that is causing symptoms
• You are reasonably active and able to care for yourself, at least some of the time (confirm with trial site)
• Your doctor estimates you are likely to live for more than 12 weeks
• You weigh more than 30 kilograms (about 66 pounds)
• Your blood cell counts are at acceptable levels (checked through a blood test; blood transfusions to reach these levels are allowed)
• Your liver is working well enough, based on blood test results
• Your kidneys are working well enough, based on blood test results
• A sample of your tumour tissue (from a previous biopsy or surgery) is available for testing
• You are willing and able to follow all the requirements of the study
• You have read and signed a consent form agreeing to take part

Who may not be able to join:

• Your cancer has spread widely or is threatening an organ in a way that your doctor feels needs stronger chemotherapy right away
• Your cancer tests positive for a specific protein called HER2 and the disease has spread to other parts of the body
• You have already received systemic (whole-body) treatment such as chemotherapy for this cancer
• You have previously had radiotherapy to your chest area (though prior radiation to bone pain spots is allowed)
• You currently have a stent (a small tube) placed in your esophagus
• You have a known abnormal opening between your esophagus and your airway (tracheo-esophageal fistula)
• The cancer has spread to your brain or the lining around your brain
• You have had a major operation within the last 28 days before starting the study
• You have been diagnosed with another cancer in the past 3 years, with some exceptions such as certain treated skin cancers (confirm with trial site)
• You have previously been treated with certain types of immunotherapy drugs that target immune checkpoint pathways (confirm with trial site)
• You have moderate or severe nerve damage causing numbness or tingling (confirm with trial site)
• You have a known allergy to any of the study drugs, or you have an active autoimmune disease (a condition where your immune system attacks your own body), such as inflammatory bowel disease, lupus, or rheumatoid arthritis — though some milder conditions like vitiligo, well-controlled thyroid problems, type 1 diabetes, or coeliac disease managed by diet may still be acceptable (confirm with trial site)
• You are currently taking steroid tablets at a moderate-to-high dose or other medicines that suppress your immune system (some forms of steroids such as inhalers or creams may still be acceptable — confirm with trial site)
• You have a current hepatitis B infection (those with a past resolved infection may still be eligible — confirm with trial site)
• You have an active hepatitis C infection
• You have HIV or active tuberculosis (TB)
• You have received a transplanted organ (such as a kidney, liver, heart, or lung) or a bone marrow transplant from a donor
• You have received a live vaccine within the last 30 days before joining the study
• You have used alternative or traditional medicines within the last 14 days before joining the study
• You have another serious uncontrolled illness, such as an active infection, uncontrolled heart or lung problems, or a mental health condition that would make it difficult to safely take part
• You are pregnant, breastfeeding, or not using reliable contraception — specific contraception requirements apply for both women and men during and after the study (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.