Phase 2 Leukaemia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with Hairy Cell Leukemia (HCL or HCLv), confirmed by a lab test, and have already received a type of chemotherapy called purine analog therapy
• You either tried a BRAF-targeted treatment and it stopped working, or you are not able to receive BRAF therapy — and you have never taken a drug called venetoclax
• You are 18 years of age or older
• You are generally able to carry out daily activities with no more than moderate limitations (confirm with trial site)
• Your liver is functioning well enough, based on standard blood test results (confirm with trial site)
• Your kidneys are functioning well enough, based on standard blood test results (confirm with trial site)
• If you have HIV, you are on effective treatment and your virus levels have been undetectable within the last 6 months
• If you have a history of Hepatitis B, your virus levels must be undetectable while on appropriate treatment
• If you have a history of Hepatitis C, you must have been successfully treated and cured, or currently be on treatment with undetectable virus levels
• If you have or have had another type of cancer, it must not interfere with this trial's treatment or results (confirm with trial site)
• If you have a history of heart problems, your heart function must meet a minimum standard based on a doctor's assessment (confirm with trial site)
• You have not received any HCL/HCLv treatment for at least 4 weeks before joining, and your disease is not currently responding to or improving from your last treatment
• Your disease is active enough to require treatment, based on specific blood counts, spleen size, or other disease-related measurements (confirm with trial site)
• You are willing and able to use reliable birth control during the treatment period and for 30 days after your last dose — this applies to both women who could become pregnant and men
• You are able to understand the study and are willing to sign a consent form (or have a legal representative do so on your behalf)
• You are able to swallow pills

Who may not be able to join:

• You have previously taken venetoclax
• You are currently taking part in another clinical trial involving an experimental treatment
• You have had a serious allergic reaction to a drug that is chemically similar to venetoclax
• You have an uncontrolled illness or serious health condition that would make joining the trial unsafe
• You are currently pregnant, as venetoclax may harm an unborn baby
• You are breastfeeding, as venetoclax may harm a nursing infant
• You have a condition that affects how your body absorbs food or medication through the digestive system
• You have received a live vaccine (such as certain flu, shingles, or other vaccines) within 4 weeks before starting, or plan to receive one during or within 30 days after completing the study treatment

Important: Always verify eligibility with the trial site directly before applying.