Non-Alcoholic Fatty Liver Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People over 18 years old whose samples and data were already collected as part of one of three earlier studies (called SERENA, REASON, and MAFALDA), and who previously agreed to genetic analysis
- People who agree to take part in this current study
From the SERENA study, people included were those who:
- Had been diagnosed with a liver condition called NAFLD (fatty liver disease)
- Were between 45 and 75 years old
- Had at least one of the following: moderate to severe liver scarring (F3–F4 fibrosis or cirrhosis) confirmed by biopsy, blood tests, or imaging; a close family member (parent, sibling, or child) with a specific type of liver cancer; or carried rare gene changes linked to liver cancer risk; OR were male with type 2 diabetes or obesity and carried at least three specific genetic variants (confirm with trial site)
From the REASON study, people included were those who:
- Were over 18 and had a liver biopsy for suspected fatty liver disease (NASH), OR had surgery involving liver tissue, OR had a liver transplant, OR had gallbladder removal surgery
From the MAFALDA study, people included were those who:
- Had weight-loss (bariatric) surgery for severe obesity (BMI of 40 or above, or BMI 35–39 with related health conditions such as uncontrolled high blood pressure, diabetes, or high cholesterol)
- Had no medical reasons preventing surgery
- Agreed to sign a consent form
Who may not be able to join:
- People who do not meet any of the inclusion criteria listed above
- People who drink alcohol above a certain threshold (more than 30g per day for men or 20g per day for women)
- People whose liver disease is caused by a viral infection, an autoimmune condition, or any other cause not related to the conditions described above
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
GP referral letter
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Trial details
Where this trial is recruiting
Primary endpoints
the main genes and expression by comparing the transcriptomic lipidomic profile; the main genes and expression by comparing the transcriptomic lipidomic profile
Can't join this trial?
Data last synced from ClinicalTrials.gov: 22 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.