Phase 1 PTSD Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are between 21 and 65 years old, including both veterans and non-veterans
• People who can read and write in English and are able to sign a consent form
• People who are willing to follow all study procedures and attend all required appointments for the full length of the study
• People whose heart tracing (ECG) shows no significant problems with heart rhythm or electrical signals
• People who have no major health reasons, based on their medical history and a brief physical check, that would make participation unsafe (as decided by the study doctor)
• People who have been diagnosed with Alcohol Use Disorder (AUD) — whether mild, moderate, or severe — based on a structured interview used by the study team
• People who have experienced at least one traumatic event in their lifetime that meets the study's definition of a qualifying trauma, confirmed through a screening interview
• People who score above 15 on a standard PTSD symptom checklist (PCL-5) before starting the study medication
• People who have had more than one heavy drinking episode in the past 30 days (defined as more than 4 standard drinks in a day for men, or more than 3 standard drinks in a day for women)
• Women who could become pregnant must be willing to use an accepted form of birth control for one month before the study and throughout participation — accepted methods include abstinence, the pill, patches, implants, a diaphragm, an IUD, or condoms

Who may not be able to join:

• People who currently have bipolar disorder or a psychotic disorder, as identified by the study's screening interview
• People who currently have a substance use disorder involving substances other than alcohol, nicotine, or marijuana
• Women who are pregnant, breastfeeding, or planning to become pregnant during the study
• People whose alcohol dependence is severe enough to require a higher level of medical care, such as a detox program, as determined by the study doctor
• People who have recently experienced serious alcohol withdrawal symptoms, withdrawal seizures, or a condition called delirium tremens (DTs)
• People who score above 4 on a standard alcohol withdrawal assessment scale (CIWA-Ar) at the screening visit
• People with a history of serious medical conditions — including liver disease, heart disease, chronic pain, or other conditions the study doctor considers unsafe for participation
• People with a significant history of heart-related conditions, including long-term high blood pressure (even if managed with medication), fainting episodes, low blood pressure when standing up, a resting heart rate below 55 beats per minute, low baseline blood pressure, or certain abnormal heart rhythm measurements on an ECG
• People with significant liver problems, including fluid build-up (ascites) or liver test results that are notably above the normal range
• People with reduced kidney function, as measured by standard blood tests
• People currently taking certain medications, including: medications approved for alcohol use disorder (such as naltrexone, disulfiram, topiramate, or acamprosate); medications that cause sedation (such as sleeping pills, barbiturates, certain antihistamines, sedating antidepressants like doxepin, mirtazapine, or trazodone, or migraine medications called triptans); blood pressure medications; certain medications that affect the nervous system (such as clonidine, guanfacine, lofexidine, or prazosin) — note that non-sedating antidepressants used for PTSD are permitted (confirm with trial site)
• People with a known allergy to the study drug, dexmedetomidine
• People who have taken part in another drug trial within the 30 days before screening
• People who have any other finding that, in the study doctor's view, would make it difficult for them to complete the study requirements

Important: Always verify eligibility with the trial site directly before applying.