Phase 3 Chronic Kidney Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who either have significantly reduced kidney function (based on a blood test result from the past 6 months), or have received dialysis (any type) within the last 7 days
- People who are scheduled to have non-heart surgery — whether planned in advance, urgent, or emergency surgery
- People who are expected to stay in hospital for at least one night after surgery
- People aged 18 or older
- People for whom written consent to take part in the BRACKETS-Pilot Trial has been obtained
Who may not be able to join:
- People undergoing heart surgery
- People undergoing brain surgery inside the skull
- People having surgery to create or fix an arteriovenous fistula or graft (a connection made in the arm or leg for dialysis)
- People for whom systemic use of tranexamic acid (TXA) or a similar medication (epsilon-aminocaproic acid) is already planned as a preventive measure
- People with a known allergy or sensitivity to tranexamic acid (TXA)
- People with a history of seizures
- People who have had a stroke, heart attack, blood clot in an artery, deep vein clot, lung clot, or clotting in a dialysis fistula or graft within the past 90 days
- People with a history of certain serious blood disorders, including thrombotic thrombocytopenic purpura, atypical hemolytic uremic syndrome, or antiphospholipid antibody syndrome
- Women who are known to be pregnant or breastfeeding, or women who could become pregnant and do not have a negative pregnancy test recorded in the 7 days before surgery, and are not using effective contraception
- People who have already taken part in the BRACKETS-Pilot Trial previously
- People at hospitals where desmopressin (a second study medication) is not available (for the desmopressin part of the trial only)
- People for whom desmopressin is already planned as a preventive treatment (for the desmopressin part of the trial only)
- People whose most recent blood sodium level was below 130 mEq/L (for the desmopressin part of the trial only) (confirm with trial site)
- People with a known or suspected bleeding disorder such as von Willebrand disease, hemophilia, or a platelet function disorder (for the desmopressin part of the trial only)
- People with a known allergy or sensitivity to desmopressin (for the desmopressin part of the trial only)
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Pavel Roshanov, MC,MSc,FRCPC, Western University
Phone: 905-296-5754
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Rate of recruitment; Receipt of the allocated study drug within 1 hour before start of surgery for the tranexamic acid factorial; Receipt of the allocated study drug within 1 hour before start of surgery for the desmopressin factorial; Completion of 30-day follow-up
Can't join this trial?
Data last synced from ClinicalTrials.gov: 15 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.