Bladder Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 70 years old.
• You have a serious bladder condition that has caused ongoing infections, poor bladder function, or damage to your kidneys and urinary tract.
• You have had bladder cancer (confined to the bladder, not spread) that required full removal of the bladder, and you have been cancer-free for an appropriate period of time — and you would need both a kidney and bladder transplant, or you already have a transplanted organ.
• You are already taking anti-rejection medication for a previously transplanted organ.
• You are willing and able to follow the treatment plan required by this trial.
• You have been fully vaccinated and boosted against COVID-19, or you are willing to get vaccinated before joining.
• You (or someone helping you at home) are able to perform a clean catheter procedure to drain the bladder, and can demonstrate this skill before the transplant.
• You do not have any other serious medical condition that the study team believes would make surgery too risky or affect the treatment plan.
• You do not have active alcohol or drug misuse problems.
• Your immune system does not react against the donor's tissue (called a "negative crossmatch").

Who may not be able to join:

• You have HIV (active or have tested positive), active Hepatitis B or C, untreated severe infection (sepsis), active tuberculosis, or certain other active infections such as chickenpox-related virus or toxoplasmosis.
• You have a blood clotting disorder such as hemophilia, Von Willebrand's disease, sickle cell disease, thalassemia, or similar inherited conditions that could increase surgical risks.
• You have certain connective tissue or immune-related conditions that can affect wound healing, such as severe rheumatoid arthritis, Ehlers-Danlos syndrome, or certain nerve disorders (confirm with trial site).
• You have a storage disease affecting the body's tissues that may interfere with nerve recovery after surgery (confirm with trial site).
• You have poor liver function, including abnormal liver blood test results or related blood clotting problems.
• You have severely low red blood cells, white blood cells, or platelets as measured by a blood test.
• You are unwilling to get vaccinated against COVID-19 before the transplant.
• You have had a cancer other than bladder cancer in the past 5 years (except for certain common skin cancers).
• You have a history of cancer that has spread to other parts of the body.
• You are unable to attend regular follow-up appointments or unable to take anti-rejection medication due to location, finances, or other reasons.
• You are a current smoker and cannot show that you have stopped smoking for at least 6 months before being listed, or you are unwilling to stay smoke-free after surgery.
• You have a documented history of not following medical advice, untreated psychological conditions, or substance misuse, or have not completed a psychological evaluation.
• The trial's medical team decides, through a group review process, that you may not be ready or able to manage the demands of this type of transplant.

Important: Always verify eligibility with the trial site directly before applying.