Multiple Sclerosis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 55 and 80 years old.
• You have been diagnosed with Multiple Sclerosis (MS).
• You have been on a stable MS medication for at least 6 months.
• You have not received physical therapy or occupational therapy in the last 6 months.
• You are able to stand up from a chair on your own, with or without holding a handrail.
• Your walking ability is moderately affected by MS, as shown by a specific walking survey score (confirm with trial site).
• You do not have any other serious conditions (such as stroke, Parkinson's disease, rheumatoid arthritis, or heart/lung problems) that affect your ability to stand or walk.
• You can understand and speak English.
• You are willing to complete all parts of the study, including wearing an activity monitor and attending assessments over 4 months.
• You feel that your memory or thinking skills have gotten worse recently (this may place you in a group being studied for mild memory/thinking changes).
• For in-person lab study (Study 1 only): You are willing and able to come to a lab twice a week for four months.
• For home-based study (Study 2 only): You have internet access and are willing to attend weekly video calls and monthly check-ins online.
• For home-based study (Study 2 only): You live with a family member.
• For home-based study (Study 2 only): You have a helper (such as a family member or friend) who can be present during home exercise sessions and online check-in calls.
• At an in-person screening, your MS-related movement difficulties fall within a specific range on a standard disability scale (confirm with trial site).
• At an in-person screening, you show signs of mild memory or thinking difficulties, based on specific memory tests (confirm with trial site).
• You are currently not physically active, based on a leisure activity questionnaire (confirm with trial site).

Who may not be able to join:

• You have had an MS relapse or worsening of symptoms in the last 3 months.
• You have had major surgery in the last 6 months or been hospitalised in the last 3 months.
• You experience shortness of breath or pain at rest that is difficult to control.
• You have high blood pressure or diabetes that is not well controlled.
• You have had a bone fracture in the last 6 months.
• You have difficulty performing everyday tasks (such as dressing or bathing), with or without a mobility aid.
• You have epilepsy or have had uncontrolled seizures in the past year.
• You currently take sedative medications (such as diazepam or lorazepam).
• You currently take medications used to treat Alzheimer's disease or dementia, or are enrolled in a trial for such medications.
• You currently take antidepressants or anti-anxiety medications.
• You are considered moderate or high risk for injury during intense physical activity, based on a standard health questionnaire (confirm with trial site).
• You have significant memory or thinking difficulties beyond mild impairment, based on a phone-based cognitive test (confirm with trial site).
• You are currently receiving any therapy for memory/thinking problems or physical rehabilitation.
• You use a pacemaker.
• At an in-person screening, your heart rate, blood pressure, or blood oxygen levels are outside safe ranges (confirm with trial site).
• At an in-person screening, you have low bone density based on a heel scan (confirm with trial site).
• You have reduced feeling in your feet, meaning you cannot feel light touch properly.
• You have severe difficulty with speaking or understanding language, based on a specific test (confirm with trial site).
• You have a nerve injury affecting your arms or legs.
• For home-based study (Study 2 only): You are at high risk of falling, based on a balance test (confirm with trial site).
• For home-based study (Study 2 only): You are unable to walk at least one block, even with a mobility aid.

Important: Always verify eligibility with the trial site directly before applying.