Bladder Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with, or are suspected of having, an advanced or metastatic cancer that includes certain types — such as non-small cell lung cancer, skin cancer (not uveal melanoma), esophageal, cervical, endometrial, liver, or colon cancer (a specific type only) — or any solid tumor with certain genetic features (high mutation burden, MSI-H, or dMMR) (confirm with trial site for your specific cancer type).
• You have advanced or metastatic kidney cancer (clear cell type) or bladder cancer, or any solid tumor that your doctor plans to treat with immunotherapy (sometimes called checkpoint inhibitor therapy).
• You have early-stage, operable triple negative breast cancer or non-small cell lung cancer, and your doctor plans to give you immunotherapy before surgery.
• Your cancer can be measured by scans or imaging (not by physical exam alone), and any area previously treated with radiation does not count as measurable disease.
• If you are receiving immunotherapy before surgery, your doctor has confirmed you are eligible for this treatment.
• If you are newly diagnosed or your cancer is suspected, you have not received any cancer treatment yet at the time of the biopsy.
• If your cancer has progressed from an earlier stage to advanced/metastatic, you have stopped any previous cancer treatment at least 2–4 weeks before the biopsy (the exact time depends on what treatment you received).
• You are generally well enough to carry out daily activities, with little to no limitation (a standard health scoring system is used to measure this — confirm with trial site).
• If you could become pregnant, you must have a negative pregnancy test within 7 days before joining the trial, and you must use appropriate contraception.
• You are willing and medically able to have either extra tissue samples taken during a routine biopsy, or a separate research-only biopsy.
• If you have a second cancer diagnosis, it does not interfere with the treatment plan for your main cancer.
• You are willing and able to sign a consent form agreeing to take part.

Who may not be able to join:

• You are currently pregnant, because the biopsy procedure involved carries more than minimal risk.
• You have other serious ongoing illnesses or health conditions that, in your doctor's opinion, would make participation unsafe or affect the results.
• You have a weakened immune system, or you are HIV positive and currently taking antiretroviral medication — however, if you are HIV positive but do not show signs of a weakened immune system, you may still be eligible (confirm with trial site).
• You have an uncontrolled or active infection, or a mental health or personal situation that would make it difficult to follow the study requirements.
• You are already enrolled in, or planning to join, another cancer treatment trial where neither you nor the research team knows which treatment you are receiving (a "blinded" trial).

Important: Always verify eligibility with the trial site directly before applying.