Phase 2 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with oral cavity cancer (confirmed by tissue testing) that has not yet been treated, at a stage of T2-4N0M0 or T1-4N1-3M0 (stages II to IVB based on a standard cancer staging system)
• People whose surgical tissue showed either no remaining cancer cells (complete response) or very few remaining cancer cells — 10% or less (major response) — after pre-surgery treatment
• People whose surgery removed all cancer with clear edges, meaning no cancer cells were found at the borders of what was removed
• People whose cancer had not spread beyond the lymph nodes into surrounding tissue
• People aged 18 to 80 years old
• People who are generally well enough to carry out daily activities, with minimal or no limitations (as measured by a standard health performance scale scoring 0 or 1)
• People with a life expectancy of more than 6 months
• Women who are able to become pregnant and agree to use contraception during treatment and for 3 months after treatment ends
• People whose pre-surgery treatment plan was decided by their treating doctor
• People who are willing to participate voluntarily and have signed a consent form

Who may not be able to join:

• Women who are pregnant or breastfeeding
• People who have had another cancer diagnosis in the past 5 years, except for certain fully treated cancers including a specific type of skin cancer (basal cell carcinoma), early-stage cervical cancer, or thyroid papilloma
• People who did not complete their pre-surgery treatment or their surgery
• People whose cancer came back or spread to other parts of the body before post-surgery radiation treatment began
• People who have medical reasons that prevent them from receiving radiation, chemotherapy, immunotherapy, or targeted therapy
• People with heart conditions or heart disease that is not well controlled
• People with serious active infections
• People with a history of immune system deficiency, including HIV, other immune conditions present from birth or developed later, or a history of organ or bone marrow transplant
• People with active tuberculosis (TB), a TB infection within the past year, or a TB infection at any time that was not properly treated
• People with active hepatitis B or hepatitis C infections above certain measurable levels in the blood
• People with a known history of substance abuse, heavy alcohol use, or drug use
• People the trial investigators consider unsuitable for participation for other medical reasons (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.