Phase 2 Leukaemia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older
• People diagnosed with a type of blood cancer called AML or ALL, where more than 5% of abnormal cells (blasts) are found in the bone marrow, with or without the cancer having spread to other parts of the body
• People whose cancer cells test positive for a specific protein called CXCR4 (at a level more than twice the control measurement) at the time of pre-screening
• People with AML or ALL who have already received treatment, but whose cancer has come back or stopped responding, and for whom no other standard treatment options are available
• People who have had at least 15 days pass since their last cancer treatment
• People who are generally able to carry out daily activities with little or no restriction (as measured by a standard medical scale called ECOG, with a score below 2)
• People whose kidneys are functioning at an adequate level (confirm specific threshold with trial site)
• People with liver enzyme levels within a certain range (confirm specific values with trial site — a different threshold may apply if leukaemia is present in the liver)
• People with bilirubin (a liver-related substance in the blood) at or below a certain level (confirm with trial site)
• Women who could become pregnant must have a documented negative pregnancy test before enrolling
• People who are fertile (male or female) and agree to use an effective form of contraception throughout the study
• People with no significant heart problems, and where the heart is pumping at more than 45% of its normal capacity
• People whose lungs are functioning above a minimum level on a specific breathing test (confirm with trial site)
• People who have signed a written consent form agreeing to take part
• People who are willing and able to attend scheduled visits and follow all study procedures
• People who are covered by, or are a beneficiary of, the French social security system

Who may not be able to join:

• People whose cancer has spread to the membranes surrounding the brain and spinal cord
• People who are HIV positive
• People with an active Hepatitis B or C infection
• People who have had an active infection within 7 days before starting treatment
• People with a current or previous second cancer, except for certain treated and resolved cancers such as a specific type of skin cancer (basal cell carcinoma), cervical cancer treated with curative intent, or another solid cancer with no signs of disease for at least one year
• People with psychological, family, social, or geographical circumstances that may make it difficult to follow the study schedule and requirements
• People already participating in another clinical trial involving experimental drugs at the same time
• People who have medical reasons they cannot receive certain supporting medications used in the study (confirm the specific medications with the trial site)
• People who have not provided written consent to participate
• Women who are pregnant or breastfeeding
• People who are under legal guardianship or trusteeship
• People who are under judicial protection

Important: Always verify eligibility with the trial site directly before applying.