Phase 2 Kidney Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 3 and 29 years old at the time of joining the study
• You have been newly diagnosed with a specific type of brain tumor called a germinoma, located in the suprasellar region (near the base of the brain) and/or the pineal region (near the center of the brain), confirmed by a tissue sample or specific blood/fluid test results
• You have two tumor spots (one in the pineal region and one in the suprasellar region), or a pineal tumor along with a condition called diabetes insipidus (a hormone-related condition causing excess thirst and urination), with specific test results within certain ranges (confirm with trial site)
• You have certain blood/fluid marker levels in a specific range that require a tissue sample to confirm the diagnosis (confirm with trial site)
• Your tumor is located in the basal ganglia or thalamus (deep brain regions)
• Your tumor has spread to other areas of the brain, fluid spaces, or spine
• Your tumor contains a mix of germinoma and mature teratoma (a type of non-cancerous growth)
• You are well enough to carry out light daily activities, as measured by a standard health performance scale
• Your eligibility has been confirmed through a central review of your brain scans
• Your brain MRI (a detailed scan using magnets) was done within 31 days before joining the trial, with and without a special dye (gadolinium)
• You had a spine MRI with special dye done before joining the trial
• You are enrolled and starting treatment no later than 31 days after surgery or diagnosis, whichever comes later
• A sample of your spinal fluid (from the lower back) was collected before joining, unless it was medically unsafe to do so
• Your spinal fluid and blood were tested for tumor markers before joining the trial
• Your blood counts are within acceptable ranges (enough white blood cells, platelets, and red blood cells), tested within 7 days before joining
• Your kidneys are working well enough, based on blood tests or urine tests appropriate for your age, tested within 7 days before joining
• Your liver is working well enough, based on blood test results within normal ranges, tested within 7 days before joining
• You are not having breathing difficulties at rest and your oxygen levels are adequate
• If you have a seizure condition, it is well managed with medication
• You do not have severe nervous system side effects (confirm with trial site)
• You are not in a medical emergency such as a coma, ongoing seizure, or on a breathing machine before joining
• If you have HIV, your virus levels are undetectable and you are on effective treatment

Who may not be able to join:

• Your tumor contains certain aggressive cancer cell types, such as yolk sac tumor, embryonal carcinoma, choriocarcinoma, malignant or immature teratoma, or a mixed germ cell tumor
• Your tumor is made up only of mature teratoma and your tumor marker tests came back normal
• You have already received any cancer treatment for this tumor other than surgery or steroids
• You are currently pregnant (note: pregnancy tests may give false results due to the tumor itself — the trial site will follow their own guidelines to check)
• You are breastfeeding and plan to continue breastfeeding during the study
• You are sexually active and able to have children but have not agreed to use effective birth control for the whole time you are in the study
• You or your parent/legal guardian has not signed the required consent form agreeing to take part
• The study does not meet all required legal and regulatory guidelines for your institution (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.