PTSD Trial, Recruiting (NCT06371404)

PTSD Trial, Recruiting NCT06371404 Sponsor: Yale University Condition: PTSD

Printed from Voxsanity (voxsanity.com.au) — NCT06371404 — Data sourced from ClinicalTrials.gov. Verify directly with the trial site before attending. Not medical advice.

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Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

You are willing and able to sign a written consent form agreeing to take part
You can read, write, and communicate clearly with the research team, and are able to follow all study instructions
You are a man or woman between 18 and 70 years old
You are in generally good health, based on a medical check-up, blood tests, urine tests, and a heart trace (ECG)
(For the PTSD group) You have a current diagnosis of PTSD based on standard diagnostic guidelines (DSM-5), confirmed by the study doctors
(For the trauma control group) You have experienced a traumatic event but have NOT been diagnosed with PTSD
(For the alcohol use disorder group) You have a current diagnosis of alcohol use disorder (AUD) based on standard diagnostic guidelines, confirmed by the study doctors
(For the alcohol use disorder group) You drink above specific amounts — men drink more than 14 drinks per week and more than 4 drinks on at least two days per week; women drink more than 7 drinks per week and more than 3 drinks on at least two days per week — and have done so for a 30-day period in the past 90 days
(For the healthy volunteer group) You have never been diagnosed with alcohol use disorder or other serious substance use problems, and you drink fewer than 5 alcoholic drinks per week with no heavy drinking days in the past 30 days

Who may not be able to join:

You have a significant ongoing medical condition affecting the nervous system, heart, hormones, kidneys, liver, or thyroid that could affect the study results (note: raised liver enzymes related to alcohol use will not automatically exclude you)
You have a current or past neurological condition affecting the brain, such as multiple sclerosis, stroke, brain tumour, traumatic brain injury with loss of consciousness, or a seizure disorder
You have a current serious psychiatric condition, including a severe substance use disorder (other than alcohol or tobacco), or a history or current experience of psychotic symptoms
You have regularly used prescription medications, herbal remedies, or other substances that affect the mind or mood (such as antidepressants, antipsychotics, or anti-anxiety medications) in the past 6 months, if these could affect the study results — note: you will not be asked to stop any medication to take part
You are currently pregnant or breastfeeding
You have donated blood within the 8 weeks before the study starts
You have a history of a bleeding disorder or are currently taking blood-thinning medications (such as Warfarin/Coumadin, Heparin, Pradaxa, or Xarelto)
You are unable to safely stop or pause the use of aspirin or anti-inflammatory painkillers (NSAIDs) for the study
You have any metal implants or devices in your body that are not safe for MRI scans (such as a pacemaker or certain artificial joints), have non-removable metal piercings, experience claustrophobia, or have worked with metal in ways that may have left fragments in your body (confirm with trial site)
You have taken part in other research studies involving radiation (such as PET scans) within the past year, in a way that would put you over the recommended yearly radiation limit
Your current or expected workplace radiation exposure, combined with the study's scans, would exceed the recommended safe limit within one year
You have any other condition that the study doctor believes would prevent you from safely following the study plan
You have a history of serious alcohol withdrawal complications, such as severe confusion (delirium tremens), seizures, or hospitalisation due to alcohol withdrawal
You are showing signs of alcohol intoxication at the time of your screening appointment
Your alcohol withdrawal score (measured using a standard scale called CIWA) is 8 or higher at the start of the study or on the day of your scan (confirm with trial site)
The study doctor does not believe you can safely go without alcohol overnight before your study visits

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.

Last synced 21 July 2026

This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Phone: 2037376969

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Voxsanity

Clinical trials and treatments, explained plainly · voxsanity.com.au

Date:

To: My Doctor

Re: Clinical trial enquiry

I am writing to enquire about the following clinical trial which may be relevant to my care:

Trial: NCT06371404

Sponsor: Yale University

Phase: Not Applicable

Status: Recruiting

Condition: PTSD

Trial contact: 2037376969

More information: https://clinicaltrials.gov/study/NCT06371404

Eligibility summary (AI generated)

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

You are willing and able to sign a written consent form agreeing to take part
You can read, write, and communicate clearly with the research team, and are able to follow all study instructions
You are a man or woman between 18 and 70 years old
You are in generally good health, based on a medical check-up, blood tests, urine tests, and a heart trace (ECG)
(For the PTSD group) You have a current diagnosis of PTSD based on standard diagnostic guidelines (DSM-5), confirmed by the study doctors
(For the trauma control group) You have experienced a traumatic event but have NOT been diagnosed with PTSD
(For the alcohol use disorder group) You have a current diagnosis of alcohol use disorder (AUD) based on standard diagnostic guidelines, confirmed by the study doctors
(For the alcohol use disorder group) You drink above specific amounts — men drink more than 14 drinks per week and more than 4 drinks on at least two days per week; women drink more than 7 drinks per week and more than 3 drinks on at least two days per week — and have done so for a 30-day period in the past 90 days
(For the healthy volunteer group) You have never been diagnosed with alcohol use disorder or other serious substance use problems, and you drink fewer than 5 alcoholic drinks per week with no heavy drinking days in the past 30 days

Who may not be able to join:

You have a significant ongoing medical condition affecting the nervous system, heart, hormones, kidneys, liver, or thyroid that could affect the study results (note: raised liver enzymes related to alcohol use will not automatically exclude you)
You have a current or past neurological condition affecting the brain, such as multiple sclerosis, stroke, brain tumour, traumatic brain injury with loss of consciousness, or a seizure disorder
You have a current serious psychiatric condition, including a severe substance use disorder (other than alcohol or tobacco), or a history or current experience of psychotic symptoms
You have regularly used prescription medications, herbal remedies, or other substances that affect the mind or mood (such as antidepressants, antipsychotics, or anti-anxiety medications) in the past 6 months, if these could affect the study results — note: you will not be asked to stop any medication to take part
You are currently pregnant or breastfeeding
You have donated blood within the 8 weeks before the study starts
You have a history of a bleeding disorder or are currently taking blood-thinning medications (such as Warfarin/Coumadin, Heparin, Pradaxa, or Xarelto)
You are unable to safely stop or pause the use of aspirin or anti-inflammatory painkillers (NSAIDs) for the study
You have any metal implants or devices in your body that are not safe for MRI scans (such as a pacemaker or certain artificial joints), have non-removable metal piercings, experience claustrophobia, or have worked with metal in ways that may have left fragments in your body (confirm with trial site)
You have taken part in other research studies involving radiation (such as PET scans) within the past year, in a way that would put you over the recommended yearly radiation limit
Your current or expected workplace radiation exposure, combined with the study's scans, would exceed the recommended safe limit within one year
You have any other condition that the study doctor believes would prevent you from safely following the study plan
You have a history of serious alcohol withdrawal complications, such as severe confusion (delirium tremens), seizures, or hospitalisation due to alcohol withdrawal
You are showing signs of alcohol intoxication at the time of your screening appointment
Your alcohol withdrawal score (measured using a standard scale called CIWA) is 8 or higher at the start of the study or on the day of your scan (confirm with trial site)
The study doctor does not believe you can safely go without alcohol overnight before your study visits

Important: Always verify eligibility with the trial site directly before applying.

Access in Australia: A treatment being studied in a clinical trial is generally not yet listed on the PBS. Where a medicine is not approved or not available through a trial, the TGA Special Access Scheme may allow a doctor to access unapproved therapeutic goods for individual patients. See voxsanity.com.au/sas-navigator/ for a plain English explainer.

This information was sourced from ClinicalTrials.gov via Voxsanity (data last synced 21 July 2026). It is not medical advice. Please verify the trial's current status directly with the trial site before acting.

Trial details

Status

Recruiting

Phase

Not Applicable

Sponsor

Yale University

Registry

ClinicalTrials.gov

Start date

5 June 2024

Est. completion

1 June 2030

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

HDAC6 expression in people with Post-Traumatic Stress Disorder; HDAC6 expression in people with Alcohol use Disorder

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 21 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov