Phase 2 Leukaemia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with extranodal NK/T-cell lymphoma (a type of lymphoma), confirmed through tissue and laboratory testing using standard diagnostic criteria.
• People whose lymphoma has come back after initially responding to treatment, has not responded to treatment, or has been newly diagnosed at an advanced stage (stage III or IV).
• People who have at least one area of disease that can be measured and tracked on a PET/CT scan, CT scan, or MRI.
• People who are expected to live for more than 3 months.
• People who are in reasonably good general health, as measured by a standard medical scoring system (ECOG score of 0–2, meaning able to carry out at least some daily activities).
• People whose recent blood test results (taken within 1 week before joining) show that blood cell counts, kidney function, liver function, and a blood protein called fibrinogen are all within the acceptable ranges set by the trial.
• People who have signed a form agreeing to take part in the trial.

Who may not be able to join:

• People whose lymphoma has spread to the brain or spinal cord, or who have another type of cancer.
• People who have previously received a type of medication called a PI3K inhibitor.
• People whose general health is too poor (ECOG score of 2 or higher) (confirm with trial site, as this overlaps with an inclusion criterion).
• People who are pregnant or breastfeeding.
• People who could potentially have children but are unwilling or unable to use effective contraception during the trial.
• People who are allergic to any of the medications used in the trial.
• People who currently have an active infection.
• People with a history of immune system deficiency, including HIV, other inherited or acquired immune conditions, or a history of organ transplant.
• People with a history of a lung condition called interstitial pneumonia, or non-infectious pneumonia, or where this condition is strongly suspected.
• People with a past history of neurological or psychiatric conditions, including epilepsy or dementia.
• People who, in the treating doctor's judgment, have other health conditions that could seriously affect their safety or their ability to complete the trial.

Important: Always verify eligibility with the trial site directly before applying.