Phase 2 Head and Neck Cancer Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You have been diagnosed with head and neck squamous cell carcinoma (a type of cancer in the throat, mouth, or voice box area) that has come back or spread, and cannot be cured with local treatments — OR (for one specific group) you have a locally advanced form of this cancer that doctors believe can be treated with surgery
- Your cancer started in one of these areas: the oropharynx (back of the throat), oral cavity (mouth), hypopharynx (lower throat), or larynx (voice box), depending on which group of the trial you are being considered for
- Depending on your group, your cancer may need to have been tested for p16 (a protein marker) and shown a negative result, OR tested positive for HPV (a virus linked to some cancers)
- You may be asked to provide results of a PD-L1 test (a marker that can affect how cancer responds to certain treatments), if those results are available
- For one specific group (Cohort 6), your cancer must be at Stage III or IVa and must be removable by surgery
- Your cancer must be measurable or detectable on scans, depending on which group you are in
- Any side effects from previous cancer treatments should have largely cleared up before starting this trial (with some exceptions, such as hair loss or mild nerve tingling)
- You must be in reasonably good general health, able to carry out normal daily activities (confirm with trial site)
- Your blood counts and organ function must meet minimum levels, including: hemoglobin (a measure of red blood cells) of at least 9 g/dL, a sufficient number of white blood cells, and platelets at an adequate level — and you must not have had a blood transfusion or certain blood-boosting treatments in the 7 days before your blood test
Who may not be able to join:
- You have a serious lung condition such as interstitial lung disease, pneumonitis (lung inflammation), or pulmonary fibrosis (lung scarring), or these conditions cannot be ruled out from your scan results
- You have cancer that has spread to the brain or spinal cord and has not been treated with surgery or radiation
- You have a history of significant heart or cardiovascular (heart and blood vessel) disease
- You have received chemotherapy, targeted therapy, immunotherapy, or any other experimental cancer treatment within the past 2 to 4 weeks before starting the trial (the exact timeframe depends on the treatment)
- You have received radiation therapy for symptom relief within the 7 days before starting the trial
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Cohorts 1, 2, 3B, 4 and 5: Objective Response Rate; Cohort 3A: Number of Participants With Dose-limiting Toxicities (DLT); Cohort 3A: Number of Participants With Treatment-emergent Adverse Events (TEAEs) as a Measure of Severity; Cohort 6: Major Pathologic Response (MPR)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 2 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.