Interstitial Lung Disease Trial, Recruiting NCT06388421 Sponsor: United Therapeutics Condition: Interstitial Lung Disease
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Interstitial Lung Disease Trial, Recruiting

NCT06388421
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • Adults aged 18 years or older
  • People who have been diagnosed with a scarring lung disease (called fibrotic ILD) confirmed by a detailed CT scan of the lungs — this includes conditions such as idiopathic pulmonary fibrosis, autoimmune-related lung scarring, chronic hypersensitivity pneumonitis, nonspecific interstitial pneumonia, occupational lung disease, or a combination of lung scarring and emphysema where the scarring is more extensive than the emphysema
  • For Groups 1–3: People whose right-heart catheterisation (a heart and lung pressure test) has confirmed high blood pressure in the lungs (pulmonary hypertension), with specific pressure measurements meeting defined thresholds (confirm with trial site)
  • For Group 1 specifically: People who are not currently using an inhaled medication called treprostinil (Tyvaso/Tyvaso DPI) at the time of enrolment
  • For Group 2 specifically: People who either started Tyvaso/Tyvaso DPI at enrolment or started it no more than 90 days before enrolment
  • For Group 3 specifically: People who have been taking Tyvaso/Tyvaso DPI at the time of enrolment and for more than 90 days before enrolment
  • For Group 4 specifically: People whose right-heart catheterisation did not meet the full definition of pulmonary hypertension but did show a specific pressure reading within a defined range (confirm with trial site)
  • People who are already taking part in other research studies may also be considered
  • People who are willing and able to give informed consent and complete surveys in English or Spanish

Who may not be able to join:

  • People with a confirmed diagnosis of pulmonary hypertension classified as Group 1, 2, 4, or 5 — though in some cases where a person has both scarring-lung-related pulmonary hypertension and another type, the treating investigator may consider enrolment if the lung scarring is judged to be the main cause (confirm with trial site)
  • People with Group 3 pulmonary hypertension caused by lung diseases or low oxygen levels other than the fibrotic lung diseases listed in the inclusion criteria
  • People who are currently using an inhaled form of treprostinil called Yutrepia at the time of enrolment — note that people using other types of pulmonary hypertension treatments may still be considered

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 27 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Phone: 919-485-8350

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Sponsor
United Therapeutics
Registry
ClinicalTrials.gov
Start date
23 January 2025
Est. completion
1 September 2030

Where this trial is recruiting

Puerto Rico 🇺🇸 United States

Primary endpoints

Baseline characteristics as described by demographics, medical history, ILD history, PH history, family history (comorbidities), and diagnostic right heart catheterization values.

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov