Phase 2 Bladder Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 20 years of age or older
• You are willing and able to sign a written consent form to participate in the study
• You have been diagnosed with high-risk non-muscle-invasive bladder cancer (a type of bladder cancer that has not grown deep into the bladder wall) that has been confirmed by a tissue sample, and you have previously received BCG treatment (a common bladder cancer therapy)
• Your most recent bladder examination or surgical procedure to remove bladder tumours was performed within the last 8 weeks before starting the trial treatment
• Your high-risk bladder cancer did not respond to BCG treatment, even after receiving it properly
• You are either not a suitable candidate for surgery to remove your bladder, or you have chosen not to have that surgery
• You are not pregnant or breastfeeding during the study period

Who may not be able to join:

• Your bladder cancer has grown into the muscle layer of the bladder wall (found during your last surgical procedure)
• Scans show that you also have cancer in the upper parts of your urinary system (such as the kidneys or ureters)
• Scans show that the cancer has spread outside the bladder
• Scans show that cancer has spread to nearby lymph nodes (glands) or to other parts of the body
• Your tissue sample shows that the cancer is mostly or entirely made up of certain rare types of cancer cells (confirm with trial site)
• You have received chemotherapy through a drip or injection for another cancer within the last 3 years
• You have had radiation therapy to the pelvic area for another cancer within the last 3 years
• You have had Mitomycin-C or gemcitabine placed directly into your bladder within the last 3 years (there may be an exception for early use after surgery — confirm with trial site)
• You have a known allergy to Mitomycin-C or gemcitabine
• A camera examination of your bladder shows a tumour in the urethral area of the prostate
• You are currently taking part in another clinical trial or have taken an experimental drug or device within the last 4 weeks
• You received chemotherapy directly into your bladder after your last bladder procedure but before starting this trial
• You have a condition that affects your blood's ability to clot, or you have low platelet levels
• You are pregnant or breastfeeding
• You have recently received a yellow fever vaccine or are taking the medication phenytoin
• You have significant liver or kidney problems (confirm with trial site)
• You have severe suppression of your bone marrow's ability to produce blood cells
• You have a severe active infection
• You have been definitively diagnosed with a scarring or inflammatory lung condition, confirmed by a chest X-ray
• You have previously had radiation therapy to your chest

Important: Always verify eligibility with the trial site directly before applying.