Early Phase 1 Obesity Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- Adults between 18 and 65 years old who can understand instructions, follow study procedures, and are willing to sign a consent form.
- People with a body mass index (BMI) between 29.0 and 37.0, meaning they are in the overweight to obese range.
- People whose excess weight is stored mostly around the belly area (upper body/visceral obesity), as measured by waist-to-hip ratio, body scans, or certain blood test results, based on specific cut-off values for men and women.
- People whose excess weight is stored mostly in the lower body (such as hips and thighs), based on waist-to-hip ratio, body scans, or blood test results, with separate definitions applying to men and women.
- Women who are not currently pregnant or breastfeeding, and who return a negative pregnancy test both at the screening stage and on the day of the inpatient visit.
- Participants must be willing to eat all meals provided by the study unit for the 3 days leading up to the study, following a specially controlled diet.
Who may not be able to join:
- People with a history of ischemic heart disease (reduced blood flow to the heart).
- People with a history of atherosclerotic valvular disease (heart valve problems caused by fatty buildup in arteries).
- People whose blood pressure remains above 160/95 even while taking blood pressure medication.
- People who currently smoke.
- People who have been diagnosed with diabetes.
- People currently taking certain medications that can affect how the body processes fats, including niacin, thiazolidinediones, beta-blockers, corticosteroids (oral or injected), or anabolic steroids.
- People with an allergy to lidocaine (a local anaesthetic).
- People with an allergy to indocyanine green (a dye used in medical imaging).
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
GP referral letter
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Trial details
Where this trial is recruiting
Primary endpoints
palmitate release
Can't join this trial?
Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.