Phase 1 Brain Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with a specific type of brain tumor (grade 2–4 glioma, IDH wild type, or glioblastoma) confirmed through lab testing of tumor tissue
• Your brain tumor has come back (recurred) after receiving standard or investigational first-line treatment, such as radiation therapy with or without chemotherapy (temozolomide) or electrical field therapy
• You are 18 years of age or older
• You are generally able to care for yourself and carry out normal activities (a performance score of 70 or higher on a standard medical scale)
• Your steroid medication dose (such as dexamethasone) has been stable or decreasing, at 6 mg or less per day, for at least 7 days before joining
• You are able to have an MRI scan with contrast dye
• Your blood counts and organ function (including white blood cells, red blood cells, platelets, liver, kidneys, and blood clotting) meet certain minimum levels, as confirmed by blood tests
• If you have a history of heart disease, your heart function must meet a certain minimum level on a standard medical scale (confirm with trial site)
• You are willing and able to follow the study plan for its full duration and can sign a written consent form
• If you are able to become pregnant or able to make someone pregnant, you must agree to use two reliable forms of contraception (or complete abstinence) from the time you consent and throughout the study, and must inform your doctor immediately if pregnancy occurs or is suspected

Who may not be able to join:

• You have another cancer (besides the brain tumor) that could interfere with your treatment or safety in this trial
• You are currently taking part in another clinical trial involving an experimental treatment (COVID-19 vaccines and treatments may be allowed — confirm with trial site)
• Not enough time has passed since your last cancer treatment — specific waiting periods apply depending on which treatment you received (confirm exact timeframes with trial site)
• You have had an allergic reaction to temozolomide, triapine, or similar medications
• Your tumor has spread to the spinal cord or the lining around the brain and spinal cord
• You have a condition called G6PD deficiency, or certain other inherited or immune-related blood disorders (all participants will be tested for G6PD before joining)
• You have uncontrolled seizures or another serious illness that is not well managed
• You are pregnant or breastfeeding, as one of the study drugs can be harmful to an unborn baby or nursing infant
• You are unable to swallow pills or tablets, or have a condition that affects how your body absorbs oral medication
• You have a known history of HIV, hepatitis B, or hepatitis C

Important: Always verify eligibility with the trial site directly before applying.