Phase 3 Transverse Myelitis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with NMOSD (Neuromyelitis Optica Spectrum Disorder).
• You have had at least 1 relapse (flare-up) of NMOSD in the past year, or at least 2 relapses in the past 2 years.
• If you are a woman who could become pregnant, your pregnancy test must be negative within 7 days before starting the study drug.
• If you or your partner could become pregnant, you agree to use reliable contraception during the study and for 6 months after finishing the study drug.
• You are willing to voluntarily take part, have fully understood the study, sign a consent form, and are able to follow and complete all study procedures.

Who may not be able to join:

• Your NMOSD is considered severe enough that the study doctor feels it would not be safe for you to participate.
• You have a long-term active immune system disease that requires ongoing treatment.
• You have received anti-CD20 therapy or other treatments that reduce certain immune cells within the past 6 months.
• You have received certain specific medications within set time periods before starting the study (confirm with trial site for details).
• You have taken part in another drug clinical trial within the past 28 days.
• You have previously received a stem cell transplant or radiation to the lymph nodes.
• You are currently pregnant, breastfeeding, or plan to have a baby during the trial.
• You had a major surgery within the 2 months before screening, or are expected to have major surgery during the trial.
• You have a severe, worsening, or uncontrolled illness that the study doctor believes puts you at higher risk.
• You have had a gastrointestinal perforation (a hole in your gut) or an abnormal internal channel (fistula) in the past 6 months.
• You received a live or weakened vaccine in the 4 weeks before starting the study, or plan to receive one during the trial.
• You currently have, or have had in the past month, a severe or ongoing infection.
• You have tested positive on a tuberculosis screening blood test (gamma interferon release test).
• You currently have active hepatitis or have a history of serious liver disease.
• You have an uncontrolled illness affecting your whole body, or any other reason the study doctor feels makes joining the trial unsuitable.
• Your laboratory (blood or urine) test results are abnormal (confirm with trial site for specific values).
• You have had a problem with alcohol or drug misuse in the past 6 months, or are currently misusing alcohol or drugs.
• You have severe mental health symptoms that make it difficult to cooperate with the study team.
• You are unable to have MRI (magnetic resonance imaging) scans during the study, or have any other condition the study doctor feels makes participation unsuitable.

Important: Always verify eligibility with the trial site directly before applying.