Phase 3 Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 75 years old (inclusive)
• You have been newly diagnosed with a specific type of lung cancer (non-small cell lung cancer, or NSCLC) that has spread locally or to other parts of the body (stage IIIB, IIIC, or IV), has a specific genetic change called an EGFR-sensitive mutation, and has not yet been treated
• Your cancer cannot be treated with surgery or radiation with curative intent
• You are willing to provide a tumor tissue sample, either previously collected or newly obtained
• You have at least one measurable tumor that can be tracked during the study
• You are generally able to carry out daily activities with little to no limitation (confirm with trial site for exact fitness level required)
• Your doctors estimate you have a life expectancy of more than 12 weeks
• You are willing and able to use reliable contraception throughout the study
• You are not pregnant at the time of screening (if applicable)
• You have read and signed the informed consent form agreeing to take part

Who may not be able to join:

• You have previously received or are currently receiving treatments targeting MET or EGFR, including certain antibody-based therapies
• You have had major surgery, certain traditional Chinese herbal medicines for cancer, or other local treatments too recently before the study starts
• You have a build-up of fluid around your lungs, abdomen, or heart that requires medical treatment
• You have recently taken certain other experimental drugs, strong medications that affect how the body processes drugs, or medications known to affect heart rhythm (confirm with trial site for exact timing)
• You are still experiencing significant side effects (Grade 2 or higher) from a previous cancer treatment
• You have a history of another type of cancer (other than the one being studied)
• You have cancer that has spread to the brain or spinal cord that is untreated or currently active
• Your blood counts or organ function (such as liver or kidneys) are not at an adequate level
• You have a serious, uncontrolled, or active heart or blood vessel condition
• You have a serious or uncontrolled illness affecting your overall health
• You have serious bleeding problems or a tendency to bleed
• You have had a serious blood clot in a vein or artery
• You have a serious or active infection
• You have an active infectious disease (confirm with trial site for specifics)
• You have a lung condition called interstitial lung disease (ILD)
• You have a serious neurological or mental health condition
• You have had a severe allergic reaction to any of the study drugs or similar medicines in the past
• You are pregnant, breastfeeding, or planning to become pregnant or breastfeed during the study or within 6 months after the last dose
• You have a history of severe allergic reactions or severe reactions to infused medications
• You have any other condition that the study doctor believes could put you at risk or affect the study results

Important: Always verify eligibility with the trial site directly before applying.