Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older who are willing and able to give written informed consent
• People who have been diagnosed with lung cancer at an early stage (cT1a–T1c, cN0)
• People who have at least one lung tumour (primary or spread from elsewhere) that is 30mm or smaller at its widest point, confirmed by a recent CT or MRI scan (ideally taken within the past 30 days)
• People whose case has been assessed by a chest surgeon as suitable for lung tumour removal surgery
• People whose target tumour has at least 5mm of clear lung tissue between it and the outer lining of the lung or a lung fissure, confirmed by recent imaging
• People who are generally active and able to carry out normal daily activities with little or no limitation (confirm with trial site regarding specific fitness scoring)
• People whose other medications have been at a stable dose for at least 4 weeks before enrolling
• People who are willing and able to attend all study visits and follow the study procedures

Who may not be able to join:

• People who are unable to give informed consent
• People for whom lung tumour removal surgery is medically unsuitable
• People whose life expectancy is estimated to be less than 12 months
• People whose target tumour is directly touching the main airway, major blood vessels of the lung, the oesophagus, or the windpipe
• People whose lung function tests show significantly reduced breathing capacity (FEV1 below 50%, total lung capacity below 80% of expected, or diffusing capacity below 60% of expected) (confirm with trial site)
• People whose blood oxygen level in normal air is below 88%, or who need more than 2 litres per minute of supplemental oxygen to keep their oxygen level at 92%
• People with a carbon dioxide level in the blood of 45mmHg or higher (confirm with trial site)
• People who have had two or more serious lung flare-ups (exacerbations) in the past year, or one or more that required hospitalisation
• People with severe emphysema, bullous emphysema, or severe chronic obstructive pulmonary disease (COPD rated GOLD stage III or IV)
• People who have had an active or prolonged lung or airway infection requiring more than 10 days of antibiotic treatment in the 21 days before screening
• People with a known history of, or current, significant bronchiectasis (a condition involving permanent widening of the airways)
• People who have large air pockets (bullae) in the lung intended for treatment that take up more than one third of that lung
• People who have had previous surgery on the lung intended for treatment
• People taking blood-thinning medication that cannot be safely stopped before the procedure, or who have a bleeding disorder, or a platelet count below 100 K/µl
• People who are pregnant, breastfeeding, or planning to become pregnant during the study
• People with severely low oxygen levels, as assessed by the treating doctor
• People who have implanted metal or electronic devices in the chest (such as a pacemaker) that cannot be removed before the procedure
• People for whom bronchoscopy (a camera examination of the airways) is medically unsuitable
• People who have taken part in another interventional clinical trial within the 30 days before signing consent
• People whom the investigator considers to be at risk from taking part in the study

Important: Always verify eligibility with the trial site directly before applying.