Phase 2 Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People between 18 and 75 years old
• People who have been diagnosed with non-small cell lung cancer confirmed through a tissue or cell sample, with additional genetic testing required if the cancer type is adenocarcinoma to rule out certain gene mutations (EGFR/ALK)
• People whose cancer has been staged as stage IIIA or IIIB (a specific sub-type involving lymph nodes no larger than 3cm, without spread beyond the lymph node capsule), confirmed through imaging or tissue biopsy of the lymph nodes in the chest
• People whose cancer — including the main tumour and any affected lymph nodes — has been assessed by a team of surgeons and specialists as potentially removable by surgery
• People who have at least one measurable tumour area based on standard imaging measurement guidelines
• People with a good general activity level (able to carry out daily activities with little or no restriction, as rated on a standard medical scale)
• People with no previous history of any other cancer
• People who have never received any treatment for their lung cancer, including surgery, radiation, chemotherapy, targeted therapy, or immunotherapy
• People whose heart and lung function meets the required levels — including breathing capacity and heart pumping function within acceptable ranges, as assessed by a surgeon
• People whose blood, liver, and kidney test results fall within the acceptable ranges required by the trial (confirm with trial site for specific values)
• People who are able and willing to use effective contraception from the time of signing the consent form until 180 days after the last dose of the study drug; women of childbearing age must also have a negative pregnancy test within 7 days before starting the study drug
• People who are willing to take part voluntarily and who have read, understood, and signed the informed consent form

Who may not be able to join:

• People whose cancer cannot be fully removed through surgery
• People who have an active autoimmune disease or a history of autoimmune conditions (such as certain types of inflammation affecting the eyes, gut, liver, pituitary gland, blood vessels, heart, kidneys, or thyroid); some exceptions may apply for certain conditions (confirm with trial site)
• People with immune deficiency conditions, including HIV infection, active hepatitis B, hepatitis C, or a combination of hepatitis B and C
• People with large, hard-to-control fluid build-up in the chest, abdomen, or around the heart
• People who have needed regular steroid medication (above a certain dose) or other immune-suppressing medications within the 14 days before starting the trial; some exceptions apply for inhaled or skin-applied steroids (confirm with trial site)
• People who have received anti-cancer vaccines or immune-stimulating treatments (such as interferon or similar therapies) within one month before starting the trial
• People currently taking part in another clinical trial, or who finished a previous clinical trial less than 4 weeks (or 5 half-lives of the trial drug) before starting this one
• People with a history of or current serious lung conditions such as pulmonary fibrosis, interstitial lung disease, or significant loss of lung function
• People who have had major surgery, an open biopsy, or a serious injury within 28 days before joining the trial
• People who have previously had an organ transplant or a bone marrow/stem cell transplant from another person
• Women who are pregnant or breastfeeding, or people who are unwilling or unable to use effective contraception
• People with a known allergy or intolerance to any of the study drugs
• People the trial investigators consider unsuitable for any other reason

Important: Always verify eligibility with the trial site directly before applying.