Phase 1 Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 75 years old
• People who have been diagnosed with leptomeningeal metastasis (cancer that has spread to the fluid and membranes surrounding the brain and spinal cord), either confirmed through spinal fluid testing or through a combination of medical history, brain scans, symptoms, and spinal fluid results
• People who have a confirmed diagnosis of lung cancer, established through tissue or cell testing combined with imaging, where standard treatments have not worked
• People whose cancer outside the brain has been stable (not growing) during treatment
• People who have been assessed by a radiation doctor as having no reasons preventing them from receiving brain and spinal radiation, and who agree to receive immunotherapy, lumbar puncture (spinal tap), chemotherapy injected into the spinal fluid, and radiotherapy
• People whose doctors estimate they are likely to live at least 3 more months and who have a general health score of 3 or below on a standard scale (confirm with trial site)
• People who agree to provide spinal fluid, blood, and tissue samples for testing
• People whose major organs (heart, lungs, liver, kidneys, bone marrow, and immune system) are functioning adequately, with no serious abnormalities
• People whose blood counts, kidney function, and liver function meet specific test result thresholds within one week before joining (confirm with trial site for exact values)
• Women who are able to become pregnant and who test negative for pregnancy within 7 days before joining, are not breastfeeding, and agree to use contraception during the trial and for 6 months after it ends; men who agree to use contraception during the trial and for 6 months after it ends

Who may not be able to join:

• People who have an active autoimmune disease or a history of autoimmune disease (where the immune system attacks the body)
• People who have a weakened immune system, either from birth or due to a medical condition
• People with heart symptoms or heart disease that is not well controlled
• People with serious infections or serious ongoing health conditions, such as a bleeding stomach ulcer, bowel blockage, heart failure, kidney failure, or poorly controlled diabetes
• People who have previously received a transplanted organ or bone marrow/stem cells from another person
• People who have had another cancer (other than lung cancer) within the past 5 years
• People who are allergic to any of the drugs used in the trial
• People with uncontrolled epilepsy, significant loss of neurological function, severe nerve damage from previous treatment, uncontrolled psychiatric conditions, or other conditions that the trial doctor considers unsuitable for participation
• Women who are pregnant or breastfeeding, or people who are able to have children but are unwilling to use effective contraception

Important: Always verify eligibility with the trial site directly before applying.