Phase 2 Bladder Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with bladder cancer (a specific type called urothelial carcinoma, including mixed types) that has been confirmed by a pathology test, at certain stages of the disease
• You are 18 years of age or older at the time of signing the consent form
• You are generally able to carry out basic daily activities — even if you use a wheelchair, you may still qualify (confirm with trial site)
• Your blood test results meet certain minimum levels for red blood cells, platelets, white blood cells, and kidney function (confirm with trial site)
• You are willing and able to use highly effective birth control starting from screening, throughout the study, and for at least 6 months after radiation is completed (applies to both men and women)
• Your doctors consider you a suitable candidate for direct treatment of the active cancer with radiation therapy

Who may not be able to join:

• You have an active autoimmune or rheumatologic condition (such as scleroderma, lupus, or ulcerative colitis) that your radiation doctor feels makes radiation therapy unsafe
• You have a psychiatric condition or substance use disorder that your doctor believes would make it difficult to take part in the trial
• Your cancer has spread to distant parts of the body (beyond nearby lymph nodes) in a way that cannot be fully targeted with radiation, in your doctor's opinion
• You have previously had radiation therapy to the pelvic area
• You are still experiencing significant side effects (Grade 2 or higher, except hair loss) from a previous cancer treatment
• You have had poorly controlled diabetes in the last 3 months, based on a specific blood sugar marker being too high and/or related symptoms (confirm with trial site)
• Your doctors estimate your life expectancy is less than 12 weeks
• You already have moderate or severe nerve damage causing numbness, tingling, or weakness (Grade 2 or higher)
• You are currently receiving intravenous (IV) antibiotics or antifungal/antiviral medications for an active infection at the time of joining the trial
• You have a known history of active Hepatitis B or Hepatitis C infection
• You have a known history of HIV infection
• You need to take high doses of steroid medications (more than 10 mg per day of prednisone or equivalent) or other medications that suppress the immune system — note that inhaled or topical steroids and low replacement doses may be allowed (confirm with trial site)
• You have a history of certain lung conditions, such as pulmonary fibrosis or drug-related lung inflammation, or signs of active lung inflammation on a recent chest scan
• You have previously received a bone marrow (stem cell) transplant from a donor or a solid organ transplant (such as a kidney or liver)
• You have active tuberculosis
• You are pregnant, breastfeeding, or planning to become pregnant during the trial period — women who could become pregnant will need a negative pregnancy test before starting radiation

Important: Always verify eligibility with the trial site directly before applying.