Phase 3 Endometriosis Trial, Recruiting NCT06439524 Sponsor: Main Line Health Condition: Endometriosis
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Phase 3 Endometriosis Trial, Recruiting

NCT06439524
Recruiting Phase 3

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People aged 18 years or older
  • People who are planning to have a scheduled (non-emergency) keyhole or robotic surgery for known or suspected endometriosis

Who may not be able to join:

  • People who have a high risk of blood clots in arteries or veins
  • People who are pregnant
  • People who have been diagnosed with osteoporosis
  • People who currently have, or have previously had, breast cancer or other cancers that are affected by hormones
  • People who have liver damage or liver disease
  • People who have unexplained unusual bleeding from the uterus that has not been diagnosed
  • People who are allergic to any ingredients in the study medication (called REL-CT)
  • People who have not stopped using certain hormonal medications within the required timeframes — specifically: skin patches, oral pills, or vaginal rings must be stopped the day before surgery; hormonal IUDs or implants must be removed during surgery; injectable hormonal medications must have been stopped at least 12 weeks before surgery
  • People whose primary spoken language is not English or Spanish
  • People who wish to become pregnant within 6 months after their surgery
  • People whose pre-surgery pregnancy test comes back positive (confirm with trial site)
  • People whose surgery does not find confirmed tissue evidence of endometriosis will be removed from the study before receiving the study treatment
  • People whose surgery becomes more extensive than planned — for example, requiring open abdominal surgery rather than keyhole surgery — will be removed from the study before receiving the study treatment

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 28 July 2026
Phase 3: approximately ~65% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Jordan Klebanoff, MD, Main Line Health

Phone: 610-896-4380

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 3
Sponsor
Main Line Health
Registry
ClinicalTrials.gov
Start date
15 August 2024
Est. completion
30 June 2028

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

This study aims to determine if immediate postoperative medical suppression with Regugolix combination therapy (Rel-CT) following excisional surgery for endometriosis is superior to surgery alone.

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov