Phase 1 Obesity Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with pre-diabetes within the last 6 months, confirmed by an accepted test
• People aged 18 years or older
• People with a Body Mass Index (BMI) between 25 and 40 (a measure of body weight relative to height)
• People whose HbA1c (a blood sugar average over roughly 3 months) is between 5.7% and 6.4%
• People whose blood pressure is below 160/100
• People whose kidneys are functioning at an acceptable level, as measured by a blood test called eGFR (confirm with trial site)
• People whose body weight has stayed within about 5 pounds over the last 3 months
• People who take water pills (diuretics), if applicable, and have been on a stable dose for at least 1 week before joining the trial
• People who identify as Hispanic
• People who are willing to follow the medication schedule for up to 6 months
• Male or female participants; female participants must meet all of the following: not currently pregnant or breastfeeding, have a negative pregnancy test at the first visit, and women who could become pregnant must use effective contraception (such as implants, pills, or have a vasectomized partner) throughout the entire study
• People who do not have severe claustrophobia (fear of enclosed spaces)
• People with no medical reasons preventing them from having an MRI scan (for example, no metal plates, screws, shrapnel, pins, or a cardiac pacemaker in their body)

Who may not be able to join:

• People who are currently taking one of the specific medications being studied in the trial (confirm with trial site)
• People who have already been diagnosed with Type 2 Diabetes
• Women who are pregnant, breastfeeding, or of childbearing age and unwilling to use contraception
• People with a known allergy or sensitivity to the study medications or their ingredients
• People who have had a major cancer diagnosis within the last 5 years
• People with current drug or alcohol use that, in the investigator's opinion, could affect their ability to follow the study requirements
• People, or their legal guardians, who are unable or unwilling to provide written consent to participate
• People with serious organ, metabolic, or physical conditions that would prevent them from completing the study
• People who have had a heart attack, heart bypass surgery, or another major heart event in the past 60 days
• People who have received a heart transplant or are on a waiting list for one
• People who currently have a mechanical heart-assist device implanted
• People with certain types of heart muscle disease or a condition causing the sac around the heart to be abnormally stiff (confirm with trial site)
• People with severe disease affecting the heart valves that is expected to require surgery during the trial
• People who have had a serious episode of heart failure requiring hospital-level treatments such as intravenous medications or mechanical support within 1 week before or during the screening period
• People who have had a heart device (implanted cardioverter defibrillator) fitted within the 3 months before screening
• People who have a cardiac resynchronization therapy device (a type of pacemaker used for heart failure)

Important: Always verify eligibility with the trial site directly before applying.