Phase 2 Lung Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are able to understand the study's purpose, agree to take part by signing a consent form, and are willing and able to follow the study procedures.
• People who are 18 years of age or older.
• People whose cancer-related physical functioning is rated at a level where they are either fully active or have only minor limitations in physical activity (ECOG score of 0 or 1).
• People whose non-small cell lung cancer (a type of lung cancer) has been confirmed through laboratory testing of tissue samples.
• People whose cancer has continued to grow or spread after at least one standard treatment, and where no approved treatment aimed at curing the cancer is available.
• People who have a tumor or spread of cancer (metastasis) in a location that can be surgically reached for tissue collection.
• People who are willing to undergo a surgical procedure, such as a removal or biopsy, to collect one or more tumor samples.
• People whose heart, lungs, blood, liver, and kidneys are functioning at an adequate level, as assessed by the treating doctor. People aged 50 or older, or those with existing heart conditions, will also need to complete a cardiac stress test.
• Women who could potentially become pregnant, who are approaching menopause, or who have been in menopause for less than two years, must have a negative blood pregnancy test before joining.

Who may not be able to join:

• People with active cancer that has spread to the brain or spinal cord. People whose brain or spinal cord metastases have been treated and have been stable for at least one month may still be considered.
• People who currently have a second active cancer.
• People with significant, uncontrolled other medical conditions that could affect their ability to follow the study — including autoimmune disorders, conditions affecting immune function, serious lung disease, or serious heart or blood vessel disease, as determined by the treating doctor.
• People who have previously had serious side effects from immune-based cancer treatments that would prevent them from safely receiving similar treatments again, as determined by the treating doctor.
• People currently taking medications that suppress the immune system in a way that would interfere with the study treatments, as determined by the treating doctor.
• People with severe active infections or infections that are not under control and require treatment.
• People with any other medical conditions, allergies, or health findings that would make it unsafe to receive any of the treatments used in the study.
• People for whom any of the planned procedures or treatments are otherwise medically unsuitable.
• Women who are pregnant, breastfeeding, or not willing to use a highly effective method of contraception throughout the study period.
• People with a known allergy or sensitivity to any of the study treatments or to substances used in the preparation of the therapy.
• People who are known to have HIV, or who test positive for HIV during screening.
• People with a known hepatitis B or hepatitis C infection.

Important: Always verify eligibility with the trial site directly before applying.