Phase 4 Migraine Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 65 years old and were seen in the emergency department
• You came in with a headache that started recently (acute headache)
• Your pain level is at least 5 out of 10 on a pain scale
• You are fully awake, alert, and know who you are, where you are, and what time it is
• You are able to understand and agree to the consent process for joining the study
• You are able to describe any side effects you might feel and rate your pain using a number scale

Who may not be able to join:

• You have a known allergy to Rimegepant or Rizatriptan (the study medications)
• You are pregnant or breastfeeding
• Your vital signs (such as blood pressure or heart rate) are unstable
• You are unable to give your consent to participate
• Your headache is suspected to be caused by something other than migraine (for example, if you have a fever of 100.4°F or higher, neurological symptoms, or need emergency brain imaging) (confirm with trial site)
• You have heart disease, including chest pain (angina), a history of heart attack, or a condition where your heart arteries go into spasm (including Prinzmetal's angina)
• You have a history of stroke or mini-stroke (TIA)
• You have problems with blood flow to your legs or arms (peripheral vascular disease)
• You have reduced blood flow to your intestines (ischemic bowel disease)
• You have high blood pressure that is not well controlled
• You are currently using or have recently used certain other headache medications, including other triptans or ergotamine-type medications
• You have a specific type of migraine called hemiplegic or basilar migraine
• You are currently taking, or have stopped within the last 2 weeks, a type of antidepressant called an MAO-A inhibitor
• You are already taking Rimegepant regularly to prevent migraines
• You are experiencing severe nausea and vomiting
• Your headache is so severe that it needs immediate emergency treatment
• You have serious liver problems
• You are currently taking any of the following medications:
  • Certain antidepressants, including MAO inhibitors (such as phenelzine, selegiline, or tranylcypromine), SSRIs (such as citalopram, escitalopram, or sertraline), duloxetine, fluoxetine, venlafaxine, or trazodone
  • Certain other migraine medications, including sumatriptan, zolmitriptan, eletriptan, frovatriptan, almotriptan, dihydroergotamine, or ergotamine
  • Certain muscle relaxants, including cyclobenzaprine
  • Certain pain medications, including tramadol
  • Certain antidepressants called tricyclics, including amitriptyline, nortriptyline, or protriptyline
  • Amphetamine-based medications such as Adderall or Dexedrine
  • Certain antifungal medications, including ketoconazole or itraconazole
  • Certain antibiotics, including clarithromycin or erythromycin
  • Certain antibiotics called rifamycins, such as rifampin or rifabutin
  • Certain seizure medications, including carbamazepine or phenytoin
  • Certain heart medications, including amiodarone, quinidine, ranolazine, or verapamil
  • Cabergoline (a medication used for various hormonal conditions)

Important: Always verify eligibility with the trial site directly before applying.