Phase 2 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with a confirmed squamous cell carcinoma (a type of cancer) located in the oropharynx (back of the throat/tonsils/base of tongue), larynx (voice box), or hypopharynx (lower throat) — the cancer must have a known starting location.
• Your cancer can be seen or measured through a physical exam or imaging scans at the main tumor site and/or in nearby lymph nodes.
• You may have had a small diagnostic lymph node removal (up to 2 nodes) or a limited surgical procedure to remove a small tonsil or base of tongue cancer.
• Your cancer is classified as Stage I through IVB (except Stage I or II glottic/voice box cancer, which is not eligible).
• You are 18 years of age or older.
• You are well enough to carry out most daily activities, with only mild limitations at most (confirm with trial site for exact fitness level required).
• You are willing and able to use reliable birth control (or abstain from sex) during treatment and for 90 days after — this applies to all men and to women who could become pregnant; if you become pregnant during the study, you must inform your doctor right away.
• Women who have not had a hysterectomy, removal of both ovaries, or natural menopause lasting at least 12 consecutive months are considered able to become pregnant and must follow the birth control requirement above.
• You are able to have a CT scan of the neck and/or an MRI of the neck, plus a PET-CT scan.
• You are able to understand the study and are willing to sign a consent form agreeing to take part.

Who may not be able to join:

• Your cancer has spread to distant parts of the body (metastasis).
• You are unable to have a CT scan with contrast dye or a planning CT scan with contrast dye.
• You are unable to have a PET-CT scan.
• Your cancer is Stage I or II glottic (voice box) cancer.
• Your entire tumor and all affected lymph nodes have already been completely surgically removed.
• You have another active cancer (other than certain low-risk prostate cancers or well-differentiated thyroid cancer) occurring at the same time outside the throat areas covered by this trial.
• You have had a previous cancer (other than certain skin cancers) within the last 3 years.
• You have previously had chemotherapy treatment for this specific cancer (prior chemotherapy for a different, past cancer may be acceptable).
• You have previously had radiation therapy in the same area of the body in a way that would overlap with radiation used in this trial.
• You are currently taking part in another clinical trial using an experimental treatment.
• You have had a serious allergic reaction to medications similar to those used in this trial (confirm with trial site).
• You have a serious uncontrolled illness such as an active infection, heart failure, unstable chest pain, irregular heartbeat, or a mental health or personal situation that the study doctors feel would make it difficult to safely take part.
• You have a history of severe immune system problems, including HIV, or have had an organ transplant or stem cell transplant.

Important: Always verify eligibility with the trial site directly before applying.