Phase 2 Endometrial Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been confirmed by lab testing to have endometrial carcinoma (cancer of the lining of the uterus), including a type called carcinosarcoma — but not uterine sarcoma.
• People who have received between 1 and 4 previous systemic (whole-body) cancer treatments, with no more than 2 of those being chemotherapy.
• People who have previously received platinum-based chemotherapy and an immunotherapy drug that targets PD-1 or PD-L1 — or, after discussion with the trial's medical team, people who were unable to receive or declined these treatments.
• People whose cancer has gotten worse during or after their last treatment, or who had to stop their last treatment due to side effects (confirm with trial site for other situations).
• People who are in generally good physical condition, rated 0 or 1 on a standard health scale (meaning fully active or able to carry out light activity), with a life expectancy of more than 6 months.
• People who have at least one tumour that can be surgically removed (to generate the treatment cells) and at least one other measurable tumour remaining after that surgery.
• People who have adequately functioning organs, including heart and lungs.
• People of childbearing potential who are willing to use a highly effective form of birth control during the trial and for up to 12 months after the last treatment dose.
• People over 70 years of age may be considered for the trial after the doctor discusses the case with the trial's medical team.

Who may not be able to join:

• People who have brain metastases (cancer that has spread to the brain) that are causing symptoms and have not been treated.
• People who have had an organ transplant from another person, or any cell-based therapy that involved preparatory chemotherapy, within the past 20 years.
• People who need regular steroid medication at a dose higher than 10 mg per day of prednisone or an equivalent steroid.
• People who have a condition where their immune system does not work properly from birth or by nature (primary immunodeficiency).
• People who have been diagnosed with another separate cancer within the past 3 years.
• People who have received, or are due to receive, a live or weakened (attenuated) vaccine within 28 days before the start of a specific part of the trial treatment (confirm with trial site for details).

Important: Always verify eligibility with the trial site directly before applying.