Phase 2 Bladder Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be 18 years of age or older.
• You have been diagnosed with a specific type of low-grade bladder cancer (called low-grade Ta urothelial carcinoma), which is either returning after a previous occurrence, a single tumor larger than 3 cm, or multiple tumors present at the same time (up to 10% high-grade cells are allowed).
• You are generally able to carry out daily activities, with only mild limitations at most (confirm with trial site).
• Scans or imaging have shown no signs of cancer in the upper urinary tract (kidneys or ureters).
• A bladder examination (cystoscopy) has shown no cancer in the urethra (the tube that carries urine out of the body).
• A bladder examination within the past 60 days has shown no visible tumors remaining.
• Your blood test shows a healthy enough level of white blood cells (neutrophils ≥ 1,500 cells/mm³).
• Your blood test shows a healthy enough level of platelets (> 100,000 cells/mm³).
• If you have or have had another type of cancer, you may still be eligible if your doctor determines it would not interfere with this trial.
• If you are able to become pregnant, you must agree to use effective birth control during the study and for at least 6 months after the last dose of the study treatment.
• If your partner can become pregnant, you must agree to use approved contraception during the study and for at least 3 months after the last dose of the study treatment.
• You must be willing to sign a consent form and agree to follow all study procedures.

Who may not be able to join:

• You have a history of high-grade bladder cancer or high-grade cancer in your upper urinary tract.
• You have previously been treated with a bladder treatment called BCG (a common immunotherapy given directly into the bladder).
• Your bladder cancer is a specific type called pure squamous cell carcinoma or adenocarcinoma.
• Your cancer includes any component of a type called neuroendocrine carcinoma.
• You have a physical condition that makes it impossible to insert a urinary catheter.
• Your bladder is too small to receive treatment delivered directly into the bladder, as determined by your urologist.
• You are able to become pregnant but are unwilling or unable to use acceptable birth control for the full study period and for at least 6 months after the last dose.
• You are currently pregnant or breastfeeding.
• You have another serious health condition that your doctor believes could make the treatment unsafe or affect the study results.
• You have received a vaccine containing a live virus within 30 days before starting the trial (for example, the nasal spray flu vaccine FluMist — note that most standard flu shots do not contain live virus and may be acceptable; confirm with trial site).
• You are currently in prison, held in a facility against your will, or are being detained for treatment of a mental health or physical health condition.

Important: Always verify eligibility with the trial site directly before applying.