Phase 3 Melanoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with one of these cancers, confirmed by laboratory testing of a tissue or cell sample within the past 5 years: non-small cell lung cancer, melanoma, breast cancer, renal cell carcinoma (a type of kidney cancer), or gastrointestinal cancer. If the original diagnosis was more than 5 years ago, more recent confirmation through testing or imaging may be accepted (confirm with trial site)
• People who have between 1 and 8 brain tumours (metastases) that have spread from the original cancer, detected on a contrast-enhanced MRI scan taken within 21 days before enrolling
• People where at least one of those brain tumours measures between 1.0 cm and 3.0 cm across at its widest point
• People whose brain tumours are located outside of the brainstem, at least 5 mm away from the optic nerves or the optic chiasm (the part of the brain connected to vision), and no larger than 3.0 cm
• People with a disease-specific prognostic score of 1.5 or higher on a standard cancer assessment scale (confirm with trial site)
• People who have no more than 2 brain lesions planned for surgical removal, if surgery is needed
• People with no known spread of cancer to the lining of the brain or spinal cord (a condition called leptomeningeal disease)
• People aged 18 or older
• People with a Karnofsky Performance Status score of 60 or above, which is a standard measure of a person's ability to carry out daily activities (confirm with trial site)
• People who have a negative pregnancy test from a urine or blood sample taken within 14 days before enrolling, if there is any possibility of pregnancy
• People who have never previously had any form of radiation treatment to the brain
• People whose heart function meets at least a Class II rating on the New York Heart Association scale, meaning their heart condition, if any, causes only slight limitations during physical activity (confirm with trial site)
• People who do not currently have an active infection that requires antibiotic treatment given through a drip (intravenously)
• People who do not have liver disease severe enough to cause yellowing of the skin or eyes (jaundice) or blood clotting problems
• People who do not have a current flare-up of a chronic lung condition or other breathing illness that would prevent participation in the trial

Who may not be able to join:

• People whose cancer diagnosis cannot be confirmed within the required timeframe through tissue testing or acceptable imaging
• People with more than 8 brain metastases, or none at all
• People whose brain tumours do not include at least one measuring between 1.0 cm and 3.0 cm
• People with brain tumours located in the brainstem, within 5 mm of the optic nerves or optic chiasm, or larger than 3.0 cm
• People with a disease-specific prognostic score below 1.5
• People who have more than 2 brain lesions planned for surgical removal
• People with known leptomeningeal disease (cancer spread to the lining of the brain or spinal cord)
• People under 18 years of age
• People with a Karnofsky Performance Status score below 60
• People who are or may be pregnant, without a recent negative pregnancy test
• People who have previously received any radiation treatment to the brain
• People with a heart function rating of Class III or IV on the New York Heart Association scale, meaning their heart condition causes significant or severe limitations
• People currently being treated with intravenous antibiotics for an active infection
• People with liver disease causing jaundice or blood clotting problems
• People currently experiencing a flare-up of a chronic lung condition or another breathing illness

Important: Always verify eligibility with the trial site directly before applying.