Phase 1 Leukaemia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with B-cell acute lymphoblastic leukaemia (B-ALL) and either have no suitable matched donor for a stem cell transplant, or have chosen not to have a stem cell transplant.
• People whose cancer cells test positive for a protein called CD19, as confirmed by a blood or bone marrow test.
• People whose heart, kidney, liver, and lung function all meet certain minimum health levels, as measured by standard tests (confirm with trial site for exact values).
• People aged between 15 and 65 years old (inclusive), of any gender.
• People whose T-cells (a type of immune cell) pass a required laboratory growth test.
• People whose doctors expect them to live for more than 3 months.

Who may not be able to join:

• People whose leukaemia has returned only in areas outside the bone marrow, or who have another type of cancer alongside their leukaemia.
• People who have previously received any treatment that targets the CD19 protein.
• People who have used immune-suppressing medications within the 2 weeks before signing the consent form, or who plan to use them after signing.
• People who have an active infection that is not currently under control.
• People who have HIV.
• People who have an active hepatitis B or hepatitis C infection.
• People who have had a serious allergic reaction to a class of antibiotics called aminoglycosides.
• People who have a significant history of, or currently have, certain neurological or psychiatric conditions — such as epilepsy, stroke, dementia, Parkinson's disease, psychosis, or severe brain injury.

Important: Always verify eligibility with the trial site directly before applying.