Phase 2 Long COVID Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older, of any gender
• You are willing and able to sign a consent form and follow all study requirements for the full duration of the trial
• You have been formally diagnosed with Long COVID by a doctor
• You had a confirmed or suspected COVID-19 infection at least 6 months before contacting the study team
• You have had Long COVID symptoms for at least 6 months
• You have had at least one of the following symptoms for at least 6 months after your COVID-19 infection: headache, memory problems, insomnia, mood changes, chest pain, heart palpitations, shortness of breath, cough, muscle pain, joint pain, or stomach/digestive issues
• You experience at least moderate fatigue, as measured by a specific fatigue scoring tool
• You experience at least moderate "post-exertional malaise" — meaning your symptoms get significantly worse after physical or mental effort — as measured by a specific screening tool
• Before getting COVID-19, your overall health score (measured by a quality-of-life scale) was 80 or above out of 100, and it is now 70 or below (confirm with trial site)

Who may not be able to join:

• You have a pre-existing autoimmune condition (such as chronic Epstein-Barr virus, Multiple Sclerosis, or Hashimoto's Disease) that could affect immune system test results
• You were diagnosed before 2020 with another post-infectious syndrome, such as Chronic Lyme disease or Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
• You have a documented history of vaccine injury
• You have any other ongoing health condition that could affect immune system testing, as decided by the research doctor
• You are HIV positive
• You are currently taking the medications Truvada or Selzentry
• You have taken certain medications within the past 6 weeks that are known to interact with Truvada or Selzentry — this includes a long list of drugs such as acyclovir, carbamazepine, diclofenac, rifampin, and several others (confirm the full list with the trial site)
• You are currently taking any medication known to affect Epstein-Barr virus (EBV), such as acyclovir, valacyclovir, ganciclovir, famciclovir, or interferon
• You have a known allergy to any ingredient in Truvada or Selzentry
• You have had a fever or illness with fever in the 3 months before your baseline study visit
• You have taken part in another clinical trial or received an experimental treatment within the past 6 months
• You have a weakened immune system — for example, if you have had an organ transplant or are taking immune-suppressing medications such as steroids
• You have a known history of active liver disease (other than a fatty liver), including hepatitis B or C, primary biliary cirrhosis, or liver failure
• You are currently receiving kidney dialysis or have known kidney problems
• You have a serious health condition that required or is expected to require hospitalization or surgery within 7 days of joining the study, or that is considered life-threatening
• You have a mental health or other medical condition that the study doctor believes makes participation unsuitable for you
• Your HIV status is unknown — you must complete HIV testing before joining the study
• You have active or latent (hidden/inactive) hepatitis B — you must complete hepatitis B blood tests before joining
• You have severe or uncontrolled problems with your kidneys, blood, digestive system, lungs, heart, or nervous system that the study doctor believes would put you at unacceptable risk
• Your kidney function (measured by a specific calculation) falls below a certain level (confirm with trial site)
• You have a history of bone fractures that were not caused by an injury
• You have low phosphate levels in your blood at a moderate or higher level of severity (confirm with trial site)
• Any of your screening test results show abnormal values at a moderate or higher level of concern (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.