Obesity Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

The trial has five separate groups, each with different requirements:

• Group 1 – Lean, young adults: People aged 18–35 with a BMI between 18.5 and 24.9 (maintained for at least 12 months)
• Group 2 – Overweight, young adults: People aged 18–35 with a BMI of 28 or higher (maintained for at least 12 months)
• Group 3 – Lean, older adults: People aged 60 or older with a BMI between 18.5 and 24.9 (maintained for at least 3 years)
• Group 4 – Overweight, older adults: People aged 60 or older with a BMI of 28 or higher (maintained for at least 3 years), divided into two subgroups: those who have a history of heart attack, coronary artery disease, stroke, peripheral artery disease, or mild-to-moderate heart failure (Subgroup A), and those with none of these conditions (Subgroup B)
• Group 5 – Nonagenerians: People aged 90 or older with a BMI of 18.5 or higher (maintained for at least 3 years)

Who may not be able to join:

For Groups 1 and 2 (young adults — lean and overweight):

• People who exercise at moderate to high intensity more than 5 times per week
• People following special diets such as a ketogenic diet or time-restricted eating
• People with significant hormone or metabolism disorders
• People with claustrophobia (fear of enclosed spaces, such as an MRI machine)
• People who use illicit drugs or drink more than 15 alcoholic drinks per week
• People with heart failure, cardiovascular disease, conditions requiring immune-suppressing medications, ongoing inflammatory diseases, or active cancer
• People with metal implants that are not compatible with a 3-Tesla MRI scan
• People who are pregnant or breastfeeding
• Group 2 only: People currently using weight-loss medications such as GLP-1 drugs (e.g. semaglutide), naltrexone, or bupropion

For Groups 3 and 4 (older adults — lean and overweight):

• People following special diets such as a ketogenic diet or time-restricted eating
• People with diabetes or an overactive or underactive thyroid
• People with claustrophobia
• People who use illicit drugs or drink more than 15 alcoholic drinks per week
• People with metal implants that are not compatible with a 3-Tesla MRI scan
• People who had heart failure, cardiovascular disease, immune-suppressing treatment, inflammatory disease, or active cancer before the age of 35
• People with a life-threatening condition or life expectancy of less than one year, or any condition that could affect their safety or ability to participate
• Group 3 only: People who exercise at moderate to high intensity more than 5 times per week
• Group 3 only: People with severe cardiovascular disease, advanced heart failure, or significantly reduced heart pumping function
• Group 4 only: People currently using weight-loss medications such as GLP-1 drugs, naltrexone, or bupropion

For Group 5 (people aged 90 and over):

• People with claustrophobia
• People with significant cognitive impairment (such as severe memory or thinking problems) that would affect their ability to take part
• People with metal implants that are not compatible with a 3-Tesla MRI scan
• People with a life-threatening condition or life expectancy of less than one year, or any condition that could affect their safety or ability to participate

Important: Always verify eligibility with the trial site directly before applying.