Phase 3 Melanoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You have agreed to take part and signed a consent form
• You are generally well enough to carry out light activity and care for yourself (confirm with trial site if unsure about your activity level)
• Your uveal melanoma (a type of eye cancer) has spread to the liver, confirmed by a biopsy or cell sample
• Your cancer can be measured on a CT scan, with at least one affected area visible in the liver
• You have not previously received treatment for your melanoma that has spread, unless you have tried a specific drug called tebentafusp and your cancer got worse, or you have had surgery or targeted treatments such as radiation or ablation to the liver
• Your doctors have decided you are a suitable candidate for a liver perfusion procedure (a specialised treatment delivered directly to the liver)
• If you are a woman who could become pregnant, you have had a negative pregnancy test within 72 hours before starting treatment
• If you are a woman who could become pregnant, you are willing to use reliable contraception during the study and for 150 days after your last dose
• If you are a man who could father a child, you are willing to use reliable contraception from your first dose until 150 days after your last dose

Who may not be able to join:

• Your doctors estimate you have less than 6 months to live
• More than half of your liver has been taken over by cancer, as seen on a CT scan
• Your cancer has spread to areas outside the liver, such as the lungs or other parts of the abdomen
• You have a history of serious heart problems, such as heart failure, unstable chest pain, a recent heart attack, significant abnormal heart rhythms, or severe heart valve disease that would make general anaesthesia unsafe
• You have serious lung disease, such as severe COPD, that would make general anaesthesia unsafe
• You are unable to have general anaesthesia for any reason
• Your kidneys are not working well enough, based on specific blood test results (confirm with trial site)
• Your liver is not working well enough, based on specific blood or scan results, or you have a history of liver scarring (cirrhosis) or high blood pressure in the liver's blood vessels (confirm with trial site)
• Your blood counts are too low, including low red blood cells, platelets, or a type of white blood cell called neutrophils (confirm with trial site)
• You have received a live vaccine within four weeks before or after study treatment
• You have had a severe allergic reaction to certain medicines used in this trial, including monoclonal antibodies, melphalan, heparin, or iodine-based contrast dye
• You have HIV, AIDS, hepatitis B, or hepatitis C
• You have an active autoimmune disease (where your immune system attacks your own body) or a history of one that needed systemic treatment — although some conditions like diabetes, rheumatoid arthritis, psoriasis, eczema, and an underactive thyroid are exceptions
• You are currently taking high-dose steroid tablets or other medicines that suppress your immune system
• You are currently receiving any other cancer treatment, immune-suppressing medication, or another experimental drug
• You have another cancer that is growing or currently being treated
• You are pregnant, breastfeeding, or planning to become pregnant or father a child during the study period or within 150 days of your last dose
• Your doctor feels that any other health condition, treatment, or test result makes it not in your best interest to take part (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.