Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• The person is at least 18 years old.
• The person has had surgery to remove as much of a glioblastoma (a type of brain tumour) as safely possible, and is able to receive standard radiation therapy (unless there is a medical reason not to, or the person declines).
• The person has a newly confirmed diagnosis of glioblastoma, identified using World Health Organization classification standards.
• Brain scan images taken before and after surgery, as well as scans used for radiation treatment planning, are available for the medical team to review.
• The person's tumour has a specific genetic characteristic called "unmethylated MGMT promoter status" (a laboratory result from tumour testing).
• The person has a Karnofsky Performance Score of 70 or higher, which means they are able to carry out normal activity with some effort and are not fully dependent on others for care (confirm with trial site).
• The person's life expectancy is more than 12 weeks.
• The person is no longer taking steroid medications (corticosteroids).
• The person has signed and dated the trial consent form.
• The person has confirmed they understand and are willing to follow all trial procedures and remain available for the full duration of the trial.

Who may not be able to join:

• The person has a tumour located in the brainstem, or the tumour is widespread or present in multiple areas of the brain, or scans suggest the tumour may have started growing back early after surgery.
• The person is pregnant, planning to become pregnant during the trial, breastfeeding, currently incarcerated, or already enrolled in another clinical trial.
• The person has a serious active infection, an autoimmune condition, a significant birth defect, another serious health condition, or has been taking immune-suppressing medications (other than Dexamethasone) within 90 days before planned device use, if the medical team considers this a reason to exclude them.
• The person has had a seizure after their brain surgery.
• The person has a medical implant or any condition that prevents them from having repeated MRI scans.
• The person has a skull defect (such as missing bone that has not been replaced), bullet fragments, or iron-containing metal in or near the head.
• The person has an active implanted electronic device, such as a heart pacemaker, vagus nerve stimulator, deep brain stimulator, or a programmable brain shunt.
• The person's blood test results show a low white blood cell count (ANC below 1,500 cells/mm³) or a low platelet count (below 100,000 cells/mm³).
• The person has previously received any treatment for a brain tumour.
• The person has recently taken part in another trial involving experimental treatments or devices that might affect this trial's results, as determined by the medical team.
• The person takes nutritional supplements or alternative health treatments that the medical team believes could affect the trial results — in particular, any products with antioxidant properties are strongly discouraged.
• The person has planned chemotherapy at the same time as or following the trial treatment.

Important: Always verify eligibility with the trial site directly before applying.