Melanoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

MELANOMA

Who might be able to join this trial:

• People who have signed a written agreement to take part and allow their tumour tissue, blood, stool samples, and standard medical information to be used for research
• People who have been confirmed by laboratory testing to have melanoma (including skin, mucosal, acral, under-the-nail, eye-related, or unknown origin melanoma) that has been surgically removed at a high-risk stage, or that cannot be surgically removed
• People whose doctors have determined them suitable to receive immunotherapy treatment
• People for whom a melanoma tissue sample taken during surgery is available, and where no systemic treatments (such as adjuvant therapy) were given between when the sample was collected and when the study test would be performed
• People who have previously received adjuvant or neoadjuvant (before or after surgery) systemic therapy may be eligible if the cancer has come back after that treatment was finished, and the tissue sample is from that returned cancer
• People whose cancer can be measured using a standard imaging measurement method called RECIST version 1.1
• People whose tissue sample comes from a full removal of the tumour (excision biopsy is preferred over a small core biopsy)
• People with an expected survival of more than 6 months
• People who have previously received certain targeted cancer drugs (BRAF/MEK inhibitors), provided all other criteria are also met
• People who have previously had radiotherapy for melanoma, as long as the tissue sample used for testing was taken from an area of the body that was not treated with radiation

Who may not be able to join:

• People who have had a positive test for active or chronic hepatitis B or hepatitis C infection (though people who have been receiving hepatitis C treatment for at least one year may still be considered eligible — confirm with trial site)
• People with a known history of HIV or AIDS

NON-MELANOMA CANCERS

Who might be able to join this trial:

• People who have signed a written agreement to take part and allow their tumour tissue and standard medical information to be used for research
• People who have been confirmed by laboratory testing to have cancer and whose doctors have determined them suitable to receive immunotherapy treatment
• People for whom a tissue sample is available where no systemic treatments were given between when the sample was collected and when the study test would be performed
• People where treatment has been given since the last tissue sample was taken may still be eligible if a new biopsy is already planned for routine care or another clinical trial — a portion of that sample could be used for this study (no new biopsy would be required solely for this study)
• People who have previously received adjuvant or neoadjuvant systemic therapy may be eligible if the cancer has come back after that treatment was finished, and the tissue sample is from that returned cancer
• People who have detectable cancer, defined by at least one of the following: cancer that can be measured using RECIST imaging criteria; cancer that shows up on a PET scan; cancer that is visible in photographs, detectable on CT scan, or able to be felt; or cancer that is evident through observable signs or symptoms
• People whose tissue sample comes from a full removal of the tumour (excision biopsy is preferred over a small core biopsy)
• People with an expected survival of more than 6 months
• People who have previously received targeted cancer therapies, provided all other criteria are also met
• People who have previously had radiotherapy, as long as the tissue sample used for testing was taken from an area of the body that was not treated with radiation

Who may not be able to join:

• People who have had a positive test for active or chronic hepatitis B or hepatitis C infection (though people who have been receiving hepatitis C treatment for at least one year may still be considered eligible — confirm with trial site)
• People with a known history of HIV or AIDS

Important: Always verify eligibility with the trial site directly before applying.