Phase 3 Bladder Cancer Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are 18 years of age or older.
- You have been diagnosed with bladder cancer that is mainly a type called urothelial carcinoma, and it has grown into the muscle wall of the bladder (confirmed by a tissue sample).
- Your cancer is at a stage where it has not spread to distant lymph nodes or other parts of the body (specific staging confirmed by imaging, and any enlarged lymph nodes must have been tested and shown to be cancer-free).
- You have little to no additional flat, non-invasive cancer spots in your bladder — having just one such spot is acceptable.
- You are in reasonably good general health and able to carry out daily activities (your doctor will assess this).
- You are able to have a pelvic MRI scan.
- Your doctors have determined you are a suitable candidate for either surgical removal of the bladder or a combined chemotherapy and radiation treatment.
- You are able to receive standard pre-surgery chemotherapy (such as certain cisplatin-based drug combinations), or other standard treatments if guidelines have been updated since the trial was designed.
- Your bladder works well enough, and you do not have a significant narrowing of the urethra, to allow for internal camera examinations of the bladder.
Who may not be able to join:
- Your bladder cancer includes certain specific subtypes (small cell or plasmacytoid) in any part of the tumour.
- You have previously received chemotherapy, immunotherapy, or certain targeted drug treatments for bladder cancer, or received such treatments for another cancer within the last 2 years.
- There is no stored bladder tumour tissue available from a previous procedure (TURBT) that can be used for genetic testing.
- You have had or currently have another type of cancer, unless it is a low-risk non-melanoma skin cancer, a very low-risk cancer not needing treatment (such as certain early prostate or breast conditions under monitoring), or you have been completely free of the other cancer for 5 or more years (some exceptions may be reviewed by the lead doctor).
- You have previously had radiation therapy to the bladder area.
- You have taken part in another experimental treatment study within the last 4 weeks.
- You have an uncontrolled serious health condition, such as an active infection currently being treated with antibiotics, significant heart failure, unstable chest pain, an uncontrolled heart rhythm problem, or a mental health or personal situation that would make it difficult to follow the study requirements.
- You are pregnant. If you could become pregnant, you must have a negative blood pregnancy test before any anaesthesia or MRI procedures.
- You are currently enrolled in another clinical trial involving an active treatment (trials focused on quality of life or supportive care are generally acceptable).
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Peter Black, MD, University of British Columbia
Phone: 604-875-5003
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Proportion of patients found to have a cCR and randomized on the number of patients enrolled (pilot-RCT ; phase 2); Metastasis free survival at 2 years (phase 3)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 23 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.