Phase 1 Bladder Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You have already tried at least one type of treatment delivered directly into the bladder (such as BCG or gemcitabine) and it did not work
• You are unwilling or unable to have BCG bladder treatment
• You have had a standard surgical procedure to remove bladder tumors (called TURBT) within the last 6 weeks, and no tumor was left behind after surgery
• You are able to provide at least 5 tissue samples from that surgery, along with the related lab reports
• Your bladder cancer has been confirmed by a lab to be a specific type (urothelial carcinoma, making up more than 50% of the tumor) and has not grown into the bladder muscle
• Your cancer is classified as "high-risk" non-muscle-invasive bladder cancer
• You are unwilling or unable to have your bladder surgically removed
• A CT scan has confirmed your cancer has not spread to lymph nodes or other parts of the body
• Your heart, bone marrow, liver, and kidneys are working well enough
• You are generally active and able to care for yourself (confirm with trial site)
• You are willing to use highly effective birth control during the study and for 180 days after your last dose; women must have a negative pregnancy blood test within 7 days before joining

Who may not be able to join:

• You have a history of bladder cancer that has grown into the muscle or spread to other parts of the body
• You have been diagnosed with another cancer in the past 3 years
• You have received any other cancer treatment within 3 weeks before starting this trial
• You have had bladder surgery or radiation therapy within 2 weeks before starting this trial
• You have had a serious allergic reaction to the study drug (9MW2821) or similar medications
• You still have significant side effects from a previous cancer treatment that have not improved sufficiently
• You have an active infection requiring treatment within the 7 days before starting the trial
• You have had a serious heart condition within the past 6 months
• You have had a bone marrow or organ transplant from another person
• You have a history of autoimmune disease (a condition where the immune system attacks the body)
• You have certain untreated or active viral infections, including hepatitis B, hepatitis C, or HIV (confirm with trial site for specific test details)
• You have previously been treated with drugs that target a protein called Nectin-4, or with a similar type of drug called an MMAE-conjugated ADC (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.