Migraine Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are 18 years of age or older at the time of signing the consent form
• People who have been diagnosed with chronic migraine (with or without aura) according to international headache classification standards, confirmed by a neurologist
• People who have had at least 8 severely debilitating headache days per month for at least 3 months in a row, where headaches seriously interfere with daily activities even after taking pain-relief medication at the recommended dose and taken early in the attack — and where at least two different triptan medications have not worked
• People who have had chronic migraine for at least 1 year before joining the trial
• People whose episodic migraines began before age 50, and whose chronic migraines began before age 65
• People whose migraines have not responded well to at least 3 of the following medication types (due to lack of effectiveness, side effects, or medical reasons why they cannot take them): certain antidepressants, certain anti-epileptic drugs, beta-blockers, calcium channel blockers, CGRP-targeting medications, certain blood pressure medications, or Botox injections
• People who have not changed their preventive headache medications (type, dose, or frequency) in the 3 months before the study begins
• People who have not used steroid tablets or steroid injections for more than 8 weeks before the study begins, and who agree to avoid these during the study and for 8 weeks after the procedure (steroid inhalers or skin treatments are not included in this restriction)
• People who agree to keep their current preventive headache medication regimen unchanged during the study and for 8 weeks after the procedure
• People whom the treating investigator considers a suitable candidate for the procedure involved in this study
• People who are able to understand and agree to the study requirements outlined in the consent form

Who may not be able to join:

• People who cannot tell the difference between their migraines and other types of headaches they experience
• People who have headaches caused by another underlying condition (though medication overuse headache is an exception)
• People who, in the investigator's opinion, have shown no or very little response to more than 6 adequate trials across the preventive medication categories listed above
• People who have changed their preventive headache medications during the baseline period of the study
• People with a current problem with drug (including narcotic) or alcohol misuse
• People who use opioid medications (such as codeine or tramadol) on more than 4 days per month, or who use any barbiturate medications
• People with other ongoing pain conditions that, in the investigator's opinion, could interfere with study procedures or make it difficult to assess results accurately
• People with other medical conditions that, in the investigator's opinion, are likely to worsen and could affect how results are measured
• People with existing medical conditions — such as bleeding or clotting disorders — that, in the investigator's opinion, would make the procedure carry too much risk
• People with significant psychological conditions, unusual pain responses, or inappropriate medication use that, in the investigator's opinion, could affect pain perception, ability to follow the study protocol, or ability to assess treatment outcomes
• People with a physical abnormality or prior injury that would make the planned procedure difficult to carry out
• People who currently have an active abscess or local infection at the site where the procedure would be performed
• People who have had a serious infection such as bone infection, or a cancer affecting the skull or procedure site, that has been active or required treatment in the past 6 months
• People who have any type of implanted electrical device that is not compatible with nerve stimulation
• People who are not able to give informed consent themselves

Important: Always verify eligibility with the trial site directly before applying.