Phase 2 Rare Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with non-small cell lung cancer (NSCLC) that cannot be removed by surgery and is classified as stage III (using standard staging guidelines).
• Your lung cancer is either of the "squamous" or "non-squamous" type (these refer to how the cancer cells look under a microscope).
• Your cancer has been found to have one of these specific genetic changes: EGFR exon 20 insertion, ROS1 fusion, RET fusion, NTRK fusion, MET exon 14, HER2, BRAF V600E, KRAS G12C, or ALK fusion (identified through a genetic test called NGS).
• Your cancer does NOT have two specific common genetic changes known as EGFR exon 19 deletion or EGFR exon 21 L858R mutation.
• You are between 18 and 75 years old (male or female).
• You are able to provide blood and tissue samples before and after treatment.
• You are generally well enough to carry out daily activities with little or no limitation (confirmed by a standard health scoring system).
• Your blood cell counts are at healthy enough levels (your doctor will check this with a blood test).
• Your liver is functioning well enough (confirmed through blood tests).
• Your kidneys are functioning well enough (confirmed through blood tests).
• You have not previously received any treatment for your lung cancer.
• You are not currently pregnant or breastfeeding.
• You are willing and able to follow the trial schedule, attend appointments, and complete all required procedures.
• You have read and signed a consent form agreeing to take part.

Who may not be able to join:

• Your doctor does not consider your cancer to be unresectable (unable to be removed by surgery) stage III disease.
• Your cancer has the specific EGFR genetic changes known as "sensitive mutations" (such as exon 19 deletion or exon 21 L858R).
• You have already had any systemic treatment (such as chemotherapy or targeted therapy) for your lung cancer.
• You currently have untreated or ongoing eye inflammation or eye infection, or a condition that makes you more likely to develop these.
• You have been diagnosed with another cancer within the last 5 years — though some exceptions may apply, such as certain skin cancers or cervical cancer in situ that were fully cured (confirm with trial site).
• You have active interstitial lung disease (a condition causing inflammation or scarring in the lungs).
• You are known to be HIV positive or have AIDS.
• You are unable or unwilling to follow the trial's procedures and requirements.
• You have an unstable or serious ongoing health condition, such as uncontrolled high blood pressure, heart failure, a heart attack within the past year, serious heart rhythm problems, active infection, active tuberculosis, or serious liver, kidney, or metabolic disease.
• You have another serious health condition that, in your doctor's opinion, could affect your ability to complete the trial or affect the results.
• You are currently pregnant or breastfeeding.
• Your cancer contains a mix of non-small cell and small cell lung cancer (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.